Incidence of Vertebral Fractures in Women with Systemic Lupus Erythematosus After 8 Years of Follow-Up

Calcified Tissue International
Mario García-CarrascoRicard Cervera

Abstract

The aim of this study was to evaluate possible associations between potential risk factors and the occurrence of established vertebral fractures (VF) in Mexican patients with systemic lupus erythematosus (SLE). Consecutive patients with SLE were enrolled in a prospective, observational study from 2006 to 2015. Information on potential risk factors, including demographics, clinical data, and bone mineral density (BMD) at the lumbar spine and hip on dual-energy X-ray absorptiometry was collected at baseline and follow-up. Semiquantitative analysis was used to determine incident VF on lateral thoracic and lumbar radiographs, defined as any vertebral body graded normal at baseline and at least mildly deformed (20-25% reduction or more in any vertebral height) during follow-up. Differences in baseline characteristics were assessed in patients with and without new radiographic VF. Of 110 SLE patients included, with a median follow-up of 8 (IQR 8-9) years, 22 (20%) had radiographic VF at baseline; 35 (32%) patients had a new VF. The annual incidence rate of new morphometric VF was 3.5 (95% CI 2.4-4.91) per 100 patient/years. Most fractures were mild or moderate and biconcave shaped. Incident VF were significantly associated with basel...Continue Reading

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Citations

Sep 14, 2017·Calcified Tissue International·Irene E M Bultink
Apr 4, 2017·Hormone Research in Pædiatrics·Galia Gat-Yablonski, Francesco De Luca
Oct 28, 2019·Climacteric : the Journal of the International Menopause Society·A Gompel
Sep 7, 2020·Clinical Rheumatology·Sujata GangulyLatika Gupta
Apr 18, 2021·Calcified Tissue International·Claudia Mendoza-PintoSocorro Méndez-Martínez

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