Incidence, outcomes, and effect on quality of life of cranial nerve injury in the Carotid Revascularization Endarterectomy versus Stenting Trial

Journal of Vascular Surgery
Robert J HyeThomas G Brott

Abstract

Cranial nerve injury (CNI) is the most common neurologic complication of carotid endarterectomy (CEA) and can cause significant chronic disability. Data from prior randomized trials are limited and provide no health-related quality of life (HRQOL) outcomes specific to CNI. Incidence of CNIs and their outcomes for patients in the Carotid Revascularization Endarterectomy vs Stenting Trial (CREST) were examined to identify factors predictive of CNI and their impact on HRQOL. Incidence of CNIs, baseline and procedural characteristics, outcomes, and HRQOL scores were evaluated in the 1151 patients randomized to CEA and undergoing surgery ≤30 days. Patients with CNI were identified and classified using case report forms, adverse event data, and clinical notes. Baseline and procedural characteristics were compared using descriptive statistics. Clinical outcomes at 1 and 12 months were analyzed. All data were adjudicated by two neurologists and a vascular surgeon. HRQOL was evaluated using the Medical Outcomes Short-Form 36 (SF-36) Health Survey to assess general health and Likert scales for disease-specific outcomes at 2 weeks, 4 weeks, and 12 months after CEA. The effect of CNI on SF-36 subscales was evaluated using random effects gr...Continue Reading

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Citations

Apr 12, 2016·International Journal of Cardiology·Hon-Kan YipCheuk-Man Yu
Sep 27, 2016·Journal of Vascular Surgery·Robert J HyeThomas G Brott
Jul 5, 2018·Korean journal of anesthesiology·Jin-Soo KimSook Young Lee
Jun 6, 2018·Stroke; a Journal of Cerebral Circulation·Douglas W JonesMarc L Schermerhorn
Apr 29, 2018·Health and Quality of Life Outcomes·Táňa FadrnáDavid Školoudík
Mar 5, 2019·The Journal of Cardiovascular Surgery·Ludovica EttorreJos C van den Berg
Feb 28, 2020·Khirurgiia·V A LukyanchikovI V Senko
Jun 24, 2017·Acta neurologica Belgica·Mariusz ChabowskiDariusz Janczak
Feb 27, 2021·Journal of Neurointerventional Surgery·Don HeckGeorge Howard
Mar 22, 2021·Progress in Cardiovascular Diseases·Don Heck, Alec Jost
Jan 10, 2020·Annals of Vascular Surgery·Anthony N GrieffSaum Rahimi
Aug 6, 2018·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Eleonora G KarthausUNKNOWN Dutch Institute for Clinical Auditing
Sep 8, 2019·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Andrew J BatchelderA Ross Naylor

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