Incidence, outcomes and prognostic factors during 25 years of treatment of chondrosarcomas

Surgical Oncology
V M van Praag VeroniekM A J van de Sande

Abstract

There are few studies detailing the incidence, patient outcomes and prognostic factors for chondrosarcomas (CS). Those that do exist have small sample sizes and/or use older datasets. The purpose of this study was to determine the incidence, overall survival (OS) and prognostic factors for OS of CS patients, as well as investigate the efficacy of curettage. We analyzed data of 2186 patients diagnosed with chondrosarcomas between '89-'13 from the Netherlands Cancer Registry. The effect of risk factors on OS was assessed with a multivariate Cox regression. Median Follow-up was determined with reversed Kaplan-Meier. OS was estimated using Kaplan-Meier method. The relative incidence of CS was 2.88 per million citizens between '89-'96, 4.15 between '96-'04 and 8.78 between '05-'13. Most of the increase in incidence came from atypical cartilaginous tumours/grade I chondrosarcoma (ACT/CS I). The 3-, 5- and 10-years survival were, respectively, 96%, 93% and 88% for ACT/CS I, 82%, 74% and 62% for grade II CS and 38%, 31% and 26% for grade III CS. Prognostics factors significantly associated with OS were age, histological grade, year of diagnosis, tumour location and size. The incidence of CS, and especially ACT/CS I, has increased over ...Continue Reading

Citations

Nov 16, 2019·Virchows Archiv : an International Journal of Pathology·Sanne VennekerJudith V M G Bovée
May 21, 2019·Clinical Orthopaedics and Related Research·Michiel E R BongersJoseph H Schwab
Jul 28, 2020·Cancers·Varun MongaMohammed Milhem
Jul 16, 2020·Skeletal Radiology·Ines OliveiraAsif Saifuddin
Feb 9, 2020·Scientific Reports·Mario D'AcuntoAlessandro Franchi
Nov 6, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Hannes EngelPia M Jungmann
Aug 21, 2020·Clinical Neurology and Neurosurgery·Mahmoud DibasAbdullah Reda
Jan 12, 2021·Frontiers in Molecular Biosciences·Ieva PalubeckaitėJudith V M G Bovée
Sep 14, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Megan E RocheAtrayee Basu-Mallick
Mar 23, 2021·Head and Neck Pathology·Tatiane Fonseca FaroJosé Rodrigues Laureano Filho
Jan 23, 2021·Advances in Anatomic Pathology·Joon Hyuk Choi, Jae Y Ro
Jun 3, 2021·Cancers·Agnieszka E ZającPiotr Rutkowski
Jul 16, 2021·JBJS Case Connector·Kelly M TomasevichAdam D Lindsay
Aug 8, 2021·Cancers·Jessie S KroonenAlfred C O Vertegaal
Apr 15, 2020·International Journal of Radiation Oncology, Biology, Physics·Mario TerlizziJuliette Thariat
Dec 17, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Matthew E WellsElizabeth M Polfer
Jan 11, 2020·Journal of Neurosurgery·Andrew S VenteicherPaul A Gardner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.