Incidence, Predictors, and Mortality of Infective Endocarditis in Adults With Congenital Heart Disease Without Prosthetic Valves

The American Journal of Cardiology
Darren MylotteAriane Marelli

Abstract

Congenital heart disease (CHD) increases the risk of infective endocarditis (IE), though the lesion-specific risk and mortality are poorly defined. Using the population-based Quebec CHD database, we sought to describe the predictors of IE and to evaluate if IE was associated with mortality among adult CHD (ACHD) patients without prior valve replacement surgery. We extracted data on ACHD patients with IE and assessed the lesion-specific incidence of IE, risk factors for IE acquisition, and all-cause 1-year mortality. Among 29,866 ACHD patients, 285 (0.95%) developed IE during follow-up period of 378,901 patient-years, from 1988-2010. The highest and lowest lesion-specific incidences of IE were observed with left-sided lesions (1.61/1000 patient-years) and patent ductus arteriosus (0.24/1000 patient-years), respectively. The following predicted the risk of IE acquisition (odds ratio (OR), 95% confidence interval [CI]): cardiac surgery in the previous 6 months (9.07, 3.98-20.67), endocardial cushion defects (6.65, 3.84-11.53), left-sided lesions (5.11, 3.60-7.25), cyanosis at birth (4.82, 3.12-7.46), ventricular septal defect (2.81, 1.87-4.21), diabetes mellitus (1.65, 1.10-2.48), and recent medical interventions (12.52, 5.23-29.9...Continue Reading

Citations

Sep 28, 2018·Congenital Heart Disease·Phong Teck LeeJu Le Tan
Sep 6, 2019·International Heart Journal·Zhi WangYi-Qing Yang
May 15, 2020·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalCristina Elena Martí-Amarista
Jul 16, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Kevin WillyGerrit Frommeyer
Nov 6, 2018·Heart and Vessels·Lan MaYi-Qing Yang
Dec 21, 2018·Journal of the American Heart Association·Courtney McCrackenLazaros Kochilas
Mar 25, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kevin WillyGerrit Frommeyer
Feb 6, 2018·Seminars in Cardiothoracic and Vascular Anesthesia·Richard J Ing, Mark D Twite

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