Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia

Heart, Lung & Circulation
John WlodarczykChristopher M Reid

Abstract

Major bleeding is a serious complication of percutaneous coronary intervention (PCI). We set out to investigate the incidence of major bleeding and its impact on hospitalisation and long-term mortality. We examined seven years of registry data encompassing 16,860 PCI procedures. Between 2005 and 2011 major bleeding increased from 1.3% to 3.4%. In patients with ST elevated myocardial infarction (STEMI), the rate increased from 2.3% to 6.4%. The increase remained significant after adjusting for patient and procedural characteristics (OR=1.09/year, p=0.001). Bleeding risk was highest in patients presenting with out-of-hospital cardiac arrest and cardiogenic shock (CS). Women, STEMI patients, those aged over 70yrs or weighing <60kg were at higher risk. Glycoprotein IIb/IIIa-inhibitor use more than doubled the risk of bleeding (OR=2.28, p=<0.001). Mortality rates at one year were 4.18% overall and 7.9% in STEMI. Bleeding was a strong predictor of mortality after adjusting for potential confounders (HR=2.92, 95% CI: 2.08, 4.09). Bleeding significantly increased length of stay (med four days vs seven days) and rehospitalisation at 12 months (OR=1.36, 95% CI: 1.08, 1.70). Major bleeding rates post-PCI appear to be increasing in Austral...Continue Reading

References

Feb 14, 2006·Heart, Lung & Circulation·A E AjaniUNKNOWN Melbourne Interventional Group investigators
Feb 14, 2007·The New England Journal of Medicine·Bo LagerqvistUNKNOWN SCAAR Study Group
May 24, 2008·The New England Journal of Medicine·Gregg W StoneUNKNOWN HORIZONS-AMI Trial Investigators
Dec 25, 2009·Circulation. Cardiovascular Interventions·Sameer K MehtaUNKNOWN National Cardiovascular Data Registry
Feb 1, 2011·Heart, Lung & Circulation·Nick AndrianopoulosChristopher M Reid
Mar 14, 2013·JAMA : the Journal of the American Medical Association·Adnan K ChhatriwallaUNKNOWN National Cardiovascular Data Registry
Aug 6, 2013·The Medical Journal of Australia·Derek P ChewDavid B Brieger

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Citations

Feb 21, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Stefan BaumannIbrahim Akin
Feb 23, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Samer NoamanUNKNOWN Melbourne Interventional Group Investigators
May 20, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Aaron N DunnStephen G Ellis
Feb 23, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·John RamzyUNKNOWN Melbourne Interventional Group (MIG)

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