Incidence, Predictors, and Outcomes of Ventriculostomy-Associated Infections in Spontaneous Intracerebral Hemorrhage

Neurocritical Care
Santosh B MurthyWendy C Ziai

Abstract

The impact of ventriculostomy-associated infections (VAI) on intracerebral hemorrhage (ICH) outcomes has not been clearly established, although prior studies have attempted to address the incidence and predictors of VAI. We aimed to explore VAI characteristics and its effect on ICH outcomes at a population level. ICH patients requiring ventriculostomy with and without VAI were identified from 2002 to 2011 Nationwide Inpatient Sample using ICD-9 codes. A retrospective cohort study was performed. Demographics, comorbidities, hospital characteristics, inpatient outcomes, and resource utilization measures were compared between the two groups. Pearson's Chi-square and Wilcoxon-Mann-Whitney tests were used for categorical and continuous variables, respectively. Logistic regression was used to analyze the predictors of VAI. We included 34,238 patients in the analysis, of whom 1934 (5.6 %) had VAI. The rate of ventriculostomy utilization in ICH increased from 5.7 % in 2002-2003 to 7.0 % in 2010-2011 (trend p < 0.001) and the rate of VAI also showed a gradual upward trend from 6.1 to 7.0 % across the same interval (trend p < 0.001). The VAI group had significantly higher inpatient mortality (41.2 vs. 36.5 %, p < 0.001) and it remained h...Continue Reading

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Citations

Sep 4, 2019·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Yusuke KatayamaTakeshi Shimazu
Apr 21, 2017·Neurology·Santosh B MurthyHooman Kamel
Aug 24, 2018·Journal of Clinical Microbiology·Ryan M MartinChristopher R Polage
Nov 2, 2017·Neurosurgical Focus·Samon TavakoliRamesh Grandhi
Sep 29, 2019·Neurocritical Care·Yasser B AbulhasanEiman M Mokaddas
Jun 29, 2016·Neurocritical Care·Santosh B MurthyWendy C Ziai
Dec 19, 2020·Expert Review of Anti-infective Therapy·Rodrigo Hasbun
Mar 21, 2021·Current Opinion in Infectious Diseases·Karen Bloch, Rodrigo Hasbun

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