Abstract
Cranial nerve involvement is commonly observed in patients with tuberculous meningitis. The present study evaluated the incidence, predictors and prognostic significance of cranial nerve involvement in tuberculous meningitis. One hundred-fifty-eight adult patients with tuberculous meningitis were retrospectively evaluated and followed up for 9 months. A detailed clinical evaluation and cranial magnetic resonance imaging were done in every patient. At inclusion, 60 (38%) patients had cranial neuropathy. Sixteen patients were having involvement of two or more cranial nerves. Abducent nerve was the most frequently (32.3%) affected cranial nerve. Predictors of cranial nerve involvement were age >25 years, history of vomiting, altered sensorium, hemiparesis, diplopia, papilledema, signs of meningeal irritation, severe functional disability, cerebrospinal fluid protein >2.5 g/L and cerebrospinal fluid cell count >100/mm(3). The presence of optochiasmatic arachnoiditis and hydrocephalus was also a significant predictor of cranial neuropathy. Presence of cranial neuropathy was significantly associated with poor outcome. Cranial nerve involvement occurred in more than one third of patients with tuberculous meningitis. The presence of cr...Continue Reading
References
Oct 31, 1998·Pediatrics·A YaramişM A Taş
Oct 12, 1999·JAMA : the Journal of the American Medical Association·C DyeM C Raviglione
Oct 22, 2004·The New England Journal of Medicine·Guy E ThwaitesJeremy J Farrar
Jul 13, 2005·Neurology India·Sunil KarandeAnagha Joshi
Jan 1, 1948·The Overseas Post-graduate Medical Journal·I A B CATHIE
Apr 16, 2009·Pediatrics·Gijs T J van WellJohan F Schoeman
Aug 1, 2009·The Journal of Infection·Guy ThwaitesUNKNOWN British Infection Society
Jan 9, 2010·Journal of the Neurological Sciences·Manish Kumar SinhaRakesh Shukla
Jul 8, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·N E AndersonM G Thomas
Citations
Jan 4, 2013·PloS One·Lidya ChaidirReinout van Crevel
Jan 8, 2013·The Journal of Infection·Tushar RautAnit Parihar
Apr 1, 2014·Journal of the Neurological Sciences·Ravindra Kumar GargNeeraj Kumar
Feb 6, 2015·Radiology Research and Practice·Morteza Sanei TaheriHosein Delavar Kasmaei
Apr 16, 2017·The Indian Journal of Tuberculosis·Baiakmenlang SynmonSuvorit Bhowmick
Nov 2, 2014·The Neurohospitalist·Kate T Brizzi, Jennifer L Lyons
Sep 8, 2012·Future Microbiology·Flavia BrancusiDorothee Heemskerk
Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Joseph R Zunt
Oct 26, 2018·Expert Review of Anti-infective Therapy·Ravindra Kumar GargNeeraj Kumar
Sep 2, 2016·The Cochrane Database of Systematic Reviews·Sophie JullienRohit Bhatia
Mar 14, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Mohammad WasayMan Mohan Mehndiratta
Aug 30, 2019·Current Opinion in Ophthalmology·Jeffrey Gluckstein, Sashank Prasad
May 2, 2019·BMC Infectious Diseases·Liming ZhangMeijia Zhu
Sep 6, 2019·Journal of Neurology·Lan WenKunyi Li
Dec 9, 2016·Neuro-ophthalmology·María García-ZamoraElena Pérez-Gutierrez
Sep 22, 2017·Current Neurology and Neuroscience Reports·Alyssa MezochowChristopher Vinnard
Jul 10, 2020·Neurology India·Manan Mayur MehtaPraveen Kumar Sharma
Mar 8, 2017·Clinical Case Reports·Shingo KonnoToshiki Fujioka
Mar 28, 2017·Expert Review of Anti-infective Therapy·Kunyi LiKebin Zeng
Jan 11, 2017·BMC Infectious Diseases·Junyan QuXiaoju Lü
Nov 7, 2019·BMC Pulmonary Medicine·Ming-Gui WangJian-Qing He
Sep 18, 2020·Journal of Clinical Medicine·Aysha ArshadVishwanath Venketaraman
Aug 3, 2018·Journal of Korean Medical Science·Sang-Ah LeeJong-Myung Lee
Jan 6, 2021·Acta neurologica Belgica·Ajith CherianK P Divya
Jan 3, 2021·Journal of the Neurological Sciences·Sarosh M Katrak
Mar 6, 2021·Breathe·Delphine NataliPhilippe Hovette
Apr 23, 2021·Scientific Reports·Mao-Shui WangXin-Jie Liu
Jun 15, 2021·Annals of Medicine·Jun-Li WangYu He