Incidence, prevalence and mortality of bullous pemphigoid in England 1998-2017: a population-based cohort study.

The British Journal of Dermatology
M S M PerssonS Gran

Abstract

A rising incidence and high mortality were found for bullous pemphigoid (BP) over a decade ago in the UK. Updated estimates of its epidemiology are required to understand the healthcare needs of an ageing population. To determine the incidence, prevalence and mortality rates of BP in England from 1998 to 2017. We conducted a cohort study of longitudinal electronic health records using the Clinical Practice Research Datalink and linked Hospital Episode Statistics. Incidence was calculated per 100 000 person-years and annual point prevalence per 100 000 people. Multivariate analysis was used to determine incidence rate ratios by sociodemographic factors. Mortality was examined in an age-, sex- and practice-matched cohort, using linked Office of National Statistics death records. Hazard ratios (HRs) were stratified by matched set. The incidence was 7·63 [95% confidence interval (CI) 7·35-7·93] per 100 000 person-years and rose with increasing age, particularly for elderly men. The annual increase in incidence was 0·9% (95% CI 0·2-1·7). The prevalence almost doubled over the observation period, reaching 47·99 (95% CI 43·09-53·46) per 100 000 people and 141·24 (95% CI 125·55-158·87) per 100 000 people over the age of 60 years. The r...Continue Reading

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Citations

Jun 17, 2020·The British Journal of Dermatology·C E Bax, V P Werth
Oct 31, 2020·Medicine·Nuntouchaporn Amonchaisakda, Kumpol Aiempanakit
May 25, 2021·Experimental Dermatology·Lula María Nieto-BenitoRicardo Suárez-Fernández
Apr 8, 2021·Deutsches Ärzteblatt International·Nina van BeekEnno Schmidt
Jun 17, 2020·The Journal of Dermatological Treatment·Pedro Miguel GarridoPaulo Filipe
Aug 10, 2021·Deutsches Ärzteblatt International·Nina van BeekEnno Schmidt
Oct 14, 2021·The Australasian Journal of Dermatology·Murat DurduSoner Uzun

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