Incidence rates and risk factors for ocular complications and vision loss in HLA-B27-associated uveitis.

American Journal of Ophthalmology
Allison R Loh, Nisha R Acharya

Abstract

To calculate the incidence rates of ocular complications and vision loss in HLA-B27-associated uveitis and to explore the effect of chronic inflammation on clinical outcomes. Retrospective longitudinal cohort study. The clinical records of 99 patients (148 uveitis-affected eyes) with HLA-B27-associated uveitis seen at a tertiary care center were included. The main outcome measures were ocular complications (posterior iris synechiae, band keratopathy, posterior subcapsular [PSC] cataracts, ocular hypertension, hypotony, cystoid macular edema, and epiretinal membrane) and vision loss. Anterior chamber inflammation was defined as ≥1+ grade inflammation. Chronic uveitis was defined as persistent inflammation with relapse in <3 months after discontinuing treatment or requiring medications to suppress inflammation for >3 months after reviewing the patient's entire clinical course. The clinical course was most commonly acute/recurrent (75%) or chronic (20%). The most common complications to develop during follow-up were ocular hypertension (0.10/eye-year) and PSC cataracts (0.09/eye-year). In multivariate analysis, the presence of posterior synechiae at presentation, inflammation, corticosteroid-sparing therapy, corticosteroid injecti...Continue Reading

References

May 1, 1975·The British Journal of Ophthalmology·R Mapstone, J C Woodrow
Nov 3, 1973·Lancet·D A BrewertonD C James
Jan 1, 1994·International Ophthalmology·V T TranC P Herbort
Feb 1, 1995·Ophthalmology·M SakamotoY Nose
Jan 1, 1996·American Journal of Ophthalmology·M L Tay-KearneyD A Jabs
May 1, 1996·Archives of Ophthalmology·A RodriguezC S Foster
Oct 1, 1998·Ophthalmology·W J PowerC S Foster
Nov 15, 2003·Current Opinion in Ophthalmology·Eric B SuhlerJames T Rosenbaum
Jun 22, 2005·Survey of Ophthalmology·John H ChangDenis Wakefield
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Nov 28, 2006·Annals of the Rheumatic Diseases·Wonuk LeeMichael H Weisman
Mar 17, 2007·American Journal of Ophthalmology·Jennifer E ThorneDouglas A Jabs
Feb 20, 2008·American Journal of Ophthalmology·Arthur M D BraakenburgAniki Rothova
Aug 9, 2008·American Journal of Ophthalmology·John H KempenSivakumar R Rathinam
Nov 26, 2008·American Journal of Ophthalmology·Eric B SuhlerDonald F Austin
May 26, 2009·Annals of the Rheumatic Diseases·J SieperB Freundlich

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Citations

Jan 24, 2014·Journal of Ophthalmology·Wendy M Smith
Sep 26, 2013·Ocular Immunology and Inflammation·Eline G van der VeerAniki Rothova
Jun 5, 2013·Ocular Immunology and Inflammation·Ilknur Tugal-TutkunEmmett T Cunningham
Jul 6, 2014·Current Eye Research·Hatice Nida SenDebra A Goldstein
Jul 17, 2012·Ophthalmology·Ebenezer DanielJohn H Kempen
Apr 3, 2012·American Journal of Ophthalmology·H Nida SenRobert B Nussenblatt
Mar 5, 2016·American Journal of Ophthalmology·Fleurieke H VerhagenJoke H de Boer
Mar 14, 2012·Ocular Immunology and Inflammation·H Nida SenUNKNOWN Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group
Mar 31, 2015·Clinical and Experimental Medicine·Marcella PreteVito Racanelli
May 8, 2016·International Ophthalmology·Serpil Yazganİsmail Doğan
May 28, 2016·Ocular Immunology and Inflammation·Laura J KopplinEric B Suhler
Jul 13, 2016·Seminars in Ophthalmology·Enzo Maria D'AmbrosioLudovico Iannetti
Jul 19, 2016·Ocular Immunology and Inflammation·Kessara PathanapitoonAniki Rothova
Sep 25, 2016·American Journal of Ophthalmology·Michael R R BöhmArnd Heiligenhaus
Mar 21, 2017·Ocular Immunology and Inflammation·Parthopratim Dutta MajumderJyotirmay Biswas
Oct 12, 2017·Ocular Immunology and Inflammation·Ji Hwan LeeChristopher Seungkyu Lee
May 1, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mirinae KimYoung-Hoon Park
Aug 28, 2018·Current Opinion in Ophthalmology·Gurdeep Jhaj, Laura J Kopplin
Nov 6, 2018·The Journal of Rheumatology·Rianne E van BentumIrene E van der Horst-Bruinsma
Jan 7, 2020·European Journal of Ophthalmology·Mar Prieto-Del-Cura, Juan Jacobo González-Guijarro
Nov 7, 2019·Vestnik oftalmologii·I Yu RazumovaI A Guseva
Apr 5, 2020·The British Journal of Ophthalmology·Haya H Al-AniRachael L Niederer
Jan 21, 2021·Journal of Clinical Medicine·Thomas El JammalPascal Sève
Jun 29, 2021·Survey of Ophthalmology·Arash MalekiC Stephen Foster
Jul 28, 2021·International Ophthalmology·Ruchika LakraParthopratim Dutta Majumder

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