Incidence rates of suicidal behaviors and treated depression in patients with and without psoriatic arthritis using the Clinical Practice Research Datalink

Modern Rheumatology
Katrina Wilcox HagbergSusan S Jick

Abstract

To estimate rates of suicidal behaviors and treated depression in patients with psoriatic arthritis (PsA) in comparison to non-PsA patients. Using the Clinical Practice Research Datalink, we conducted a cohort study of patients with PsA compared to non-PsA patients. Patients with codes for suicidal behaviors (ideation, attempts, and suicide) and treated depression (diagnosis plus anti-depressant prescription) recorded during follow-up were identified as cases. We estimated incidence rates (IRs) and incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for each outcome and stratified results in the PsA cohort by receipt of systemic PsA drugs. The rates of suicide ideation, attempt, and suicide were similar for PsA and non-PsA patients [IRR = 0.99 (95%CI: 0.67-1.47), IRR = 1.07 (95%CI: 0.86-1.34), and 0.34 (95%CI: 0.05-2.48), respectively] and rates of suicidal behaviors were slightly higher among PsA patients who received PsA drugs compared to those who did not. PsA patients had slightly higher rate of treated depression compared to non-PsA patients [IRR = 1.38 (95%CI: 1.27-1.49)] and were significantly higher in PsA patients who received drugs [IRR = 1.59 (95%CI: 1.35-1.86)]. Rate of depression was higher in patients...Continue Reading

References

May 1, 1979·International Journal of Bio-medical Computing·S Niazi
Aug 26, 1998·QJM : Monthly Journal of the Association of Physicians·D H LawsonJ Hollowell
May 14, 2003·Pharmacotherapy·Susan S JickHershel Jick
Dec 19, 2007·Archives of Dermatology·Consuelo HuertaLuis A García Rodríguez
Feb 18, 2011·The Journal of Rheumatology·Alberto CauliUNKNOWN GRAPPA 3PPsA Study Group
Dec 14, 2011·The New England Journal of Medicine·Iain B McInnes, Georg Schett
Mar 12, 2013·Arthritis·Marina N MagreyMuhammad Asim Khan
Apr 3, 2014·The Journal of Rheumatology·Emily McDonoughDafna D Gladman
Aug 13, 2015·Best Practice & Research. Clinical Rheumatology·Leslie J Crofford

❮ Previous
Next ❯

Citations

Feb 19, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·J J WuG Simon
Dec 22, 2017·Rheumatology International·Elena P CalandreMahmoud Slim
Dec 3, 2020·Journal of Cutaneous Medicine and Surgery·Aysha LukmanjiKaren L Tang
Mar 18, 2020·Seminars in Arthritis and Rheumatism·Enav Z ZusmanMary A De Vera
Aug 15, 2017·Seminars in Arthritis and Rheumatism·M Elaine HusniSara Davin

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.