Incidence, risk factors, and clinical implications of post-operative delirium in lung transplant recipients

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Brian J AndersonJ M Diamond

Abstract

Delirium significantly affects post-operative outcomes, but the incidence, risk factors, and long-term impact of delirium in lung transplant recipients have not been well studied. We analyzed 155 lung transplant recipients enrolled in the Lung Transplant Outcomes Group (LTOG) cohort at a single center. We determined delirium incidence by structured chart review, identified risk factors for delirium, determined whether plasma concentrations of 2 cerebral injury markers (neuron-specific enolase [NSE] and glial fibrillary acidic protein [GFAP]) were associated with delirium, and determined the association of post-operative delirium with 1-year survival. Fifty-seven (36.8%) patients developed post-operative delirium. Independent risk factors for delirium included pre-transplant benzodiazepine prescription (relative risk [RR] 1.82; 95% confidence interval [CI] 1.08 to 3.07; p = 0.025), total ischemic time (RR 1.10 per 30-minute increase; 95% CI 1.01 to 1.21; p = 0.027), duration of time with intra-operative mean arterial pressure <60 mm Hg (RR 1.07 per 15-minute increase; 95% CI 1.00 to 1.14; p = 0.041), and Grade 3 primary graft dysfunction (RR 2.13; 95% CI 1.27 to 3.58; p = 0.004). Ninety-one (58.7%) patients had plasma available ...Continue Reading

Citations

Dec 22, 2019·Journal of Clinical Psychology in Medical Settings·Yelena Chernyak, Lisa Teh
Sep 26, 2020·Journal of the American Geriatrics Society·Sophia WangBabar Khan
May 9, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Justin N TawilMichael L Boisen
Feb 1, 2019·Intensive Care Medicine·R SonnevilleM C Brouwer
Jan 23, 2021·International Journal of Environmental Research and Public Health·Marcelina CzokŁukasz J Krzych
May 26, 2021·Harvard Review of Psychiatry·Laura E GibbonsSejal B Shah
Sep 23, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Patrick SmithAnthony D Sung
Jan 18, 2022·International Psychogeriatrics·Sophia WangBabar Khan

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