Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors

Epilepsia
Nicole J UllrichTobias Loddenkemper

Abstract

Seizures are common during and after treatment for a primary brain tumor. Our objective was to describe the incidence and risk factors for seizures in long-term survivors of pediatric brain tumors. In a retrospective, longitudinal study, we reviewed all consecutive patients during a 12-month period who were at least 2 years post initial diagnosis of a brain tumor. Data collection included age at diagnosis, length of follow-up, extent of initial resection, tumor histology, and treatment modalities. For patients who had experienced seizures at any time, the timing and frequency of seizures, seizure semiology, electroencephalography results, and anticonvulsant use were recorded. Univariate analyses and logistic regression were performed to assess risk factors. The cohort included 298 patients (140 female). Average duration of follow-up was 7.6 years. Initial surgical resection was gross-total in 109 patients, and subtotal for 143. Twenty-nine patients underwent biopsy alone and 17 had no surgical intervention. Tumor location included posterior fossa (104; 36%), midline (98; 34%), cortical (85; 29%), and other (11; 3%). Most frequent diagnoses were low grade glioma, medulloblastoma, and ependymoma. Other treatments included cranial...Continue Reading

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Citations

Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthew T Brown, Frederick A Boop
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Luca MatteiFrancesco DiMeco
Oct 11, 2019·Current Opinion in Pediatrics·Celiane Rey-CasserlyUNKNOWN Boston Childrenʼs Hospital
Jan 25, 2020·Acta Paediatrica·Einar StensvoldPetter Brandal
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Jul 23, 2021·Advanced Science·Elise P W JenkinsGeorge G Malliaras

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