Incident AIDS or Death After Initiation of Human Immunodeficiency Virus Treatment Regimens Including Raltegravir or Efavirenz Among Adults in the United States

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Stephen R ColeCenters for AIDS Research Network of Integrated Clinical Systems (CNICS) Investigators

Abstract

The long-term effectiveness of human immunodeficiency virus (HIV) treatments containing integrase inhibitors is unknown. We use observational data from the Centers for AIDS Research Network of Integrated Clinical Systems and the Centers for Disease Control and Prevention to estimate 4-year risk of AIDS and all-cause mortality among 415 patients starting a raltegravir regimen compared to 2646 starting an efavirenz regimen (both regimens include emtricitabine and tenofovir disoproxil fumarate). We account for confounding and selection bias as well as generalizability by standardization for measured variables, and present both observational intent-to-treat and per-protocol estimates. At treatment initiation, 12% of patients were female, 36% black, 13% Hispanic; median age was 37 years, CD4 count 321 cells/µL, and viral load 4.5 log10 copies/mL. Two hundred thirty-five patients incurred an AIDS-defining illness or died, and 741 patients left follow-up. After accounting for measured differences, the 4-year risk was similar among those starting both regimens (ie, intent-to treat hazard ratio [HR], 0.96 [95% confidence interval {CI}, .63-1.45]; risk difference, -0.9 [95% CI, -4.5 to 2.7]), as well as among those remaining on regimens ...Continue Reading

References

Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Oct 31, 2003·American Journal of Epidemiology·Wayne A Ray
Feb 12, 2008·International Journal of Epidemiology·Mari M KitahataMichael S Saag
Apr 21, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey L LennoxUNKNOWN STARTMRK Investigators
Sep 29, 2011·Clinical Trials : Journal of the Society for Clinical Trials·Miguel A Hernán, Sonia Hernández-Díaz
Nov 8, 2013·The New England Journal of Medicine·Sharon L WalmsleyUNKNOWN SINGLE Investigators
Sep 4, 2014·AIDS Research and Human Retroviruses·Ashley L BuchananAdaora A Adimora
Oct 29, 2015·American Journal of Epidemiology·M Alan Brookhart
Aug 24, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael S SaagUNKNOWN CFAR Network of Integrated Clinical Systems (CNICS)

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Citations

Jul 16, 2020·The Journal of Antimicrobial Chemotherapy·Belén AlejosUNKNOWN CoRIS
Aug 12, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Haidong LuRichard D Moore
May 26, 2021·AIDS Research and Human Retroviruses·Stockton MayerUNKNOWN HIV Outpatient Study Investigators
Dec 23, 2021·AIDS·Haidong LuUNKNOWN North American AIDS Cohort Collaboration on Research, Design of the International Epidemiologic Databases to Evaluate AIDS
Dec 23, 2021·AIDS·Juan V Guanira, Carl J Fichtenbaum

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