Incident hand OA is strongly associated with reduced peripheral blood leukocyte telomere length

Osteoarthritis and Cartilage
Timothy E McAlindonCharles B Eaton

Abstract

To evaluate the relationship of telomere length to the prevalence and incidence of hand osteoarthritis in a longitudinal cohort. We conducted a cross-sectional and longitudinal analysis of data from a subset of participants in the Osteoarthritis Initiative (OAI) recruited between February 2004 and May 2006. 274 individuals were eligible for the study based on availability of both baseline and 48-month hand radiographs and peripheral blood leucocyte telomere length data. Mean telomere length of peripheral blood leukocytes (PBL)s from the DNA samples was determined using a validated quantitative polymerase chain reaction (PCR)-based assay, and hand radiographs were analyzed and graded using the Kellgren-Lawrence scale. In joint -level analyses, prevalent Interphalangeal Joint Osteoarthritis (IPJOA) was significantly associated with PBL telomere length in the baseline sample in unadjusted analyses (RR = 2.84; 95% CI:0.87-9.29) or in models adjusted for age, sex, and body mass index (aRR = 1.10; 95% CI: 0.96-1.27). The association in crude and adjusted analyses appeared slightly stronger with incident IPJOA, especially in the subset with normal hands at baseline (aRR = 1.62; 95% CI: 1.02-2.57). PBL telomere length was also associat...Continue Reading

Citations

Feb 28, 2020·Experimental and Therapeutic Medicine·Persefoni FragkiadakiAristidis Tsatsakis
Jul 4, 2021·Current Rheumatology Reports·Benjamin PlotzJonathan Samuels
Jul 28, 2021·Aging Clinical and Experimental Research·Huimin XieFaming Pan
Oct 23, 2021·Frontiers in Genetics·Jing YangYingjun Li

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