Incident opioid drug use among older adults with chronic obstructive pulmonary disease: a population-based cohort study

British Journal of Clinical Pharmacology
Nicholas T VozorisPaula A Rochon

Abstract

The purpose of the present study was to describe the scope, pattern and patient characteristics associated with incident opioid use among older adults with chronic obstructive pulmonary disease (COPD). This was a retrospective population-based cohort study using Ontario, Canada, healthcare administrative data. Study participants were individuals aged 66 years and older with physician-diagnosed COPD, identified using a validated algorithm, who were not receiving palliative care. We examined the incidence of oral opioid receipt between 1 April 2003 and 31 March 2012, as well as several patterns of incident opioid drug use. Among 107,109 community-dwelling and 16,207 long-term care resident older adults with COPD, 72,962 (68.1%) and 8811 (54.4%), respectively, received an incident opioid drug during the observation period. Among long-term care residents, multiple opioid dispensings (8.8%), dispensings for >30 days' duration (up to 19.8%), second dispensings (35-43%) and early refills (24.2%) were observed. Incident opioid dispensing was also observed to occur during COPD exacerbations (6.9% among all long-term care residents; 18.1% among long-term care residents with frequent exacerbations). These same patterns of incident opioid ...Continue Reading

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Citations

Nov 26, 2015·British Journal of Clinical Pharmacology·Nicholas T VozorisDenis E O'Donnell
Nov 27, 2015·British Journal of Clinical Pharmacology·David C CurrowMiriam J Johnson
Dec 4, 2015·British Journal of Clinical Pharmacology·D M Van Renterghem
Apr 27, 2016·Expert Review of Respiratory Medicine·Denis E O'DonnellJ Alberto Neder
Nov 2, 2016·The European Respiratory Journal·Nicholas T VozorisPaula A Rochon
Dec 3, 2016·The European Respiratory Journal·Nicholas T VozorisSudeep S Gill
Sep 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Denis E O'DonnellDonald A Mahler
May 27, 2017·The European Respiratory Journal·John PolitisNatasha Smallwood
May 27, 2017·The European Respiratory Journal·Miriam J JohnsonDavid C Currow
Jul 16, 2016·The European Respiratory Journal·Nicholas T VozorisPaula A Rochon
Jun 24, 2017·The European Respiratory Journal·Natasha SmallwoodBrian Le
Jun 24, 2017·The European Respiratory Journal·Nicholas T Vozoris
Mar 10, 2017·The European Respiratory Journal·Nicholas T VozorisPaula A Rochon
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Jul 1, 2017·European Journal of Clinical Pharmacology·Nicholas T VozorisPaula A Rochon
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Nov 2, 2019·Advances in Therapy·Denis E O'DonnellJ Alberto Neder

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