Incidental adrenal lesions: accuracy of characterization with contrast-enhanced washout multidetector CT--10-minute delayed imaging protocol revisited in a large patient cohort

Radiology
Minal J SangwaiyaPeter F Hahn

Abstract

To reassess the accuracy of the 10-minute delayed scan to differentiate both lipid-rich and lipid-poor lesions in a large cohort of patients. This HIPAA-compliant retrospective study had institutional review board approval; the need for informed consent was waived. A multidetector computed tomography (CT) adrenal protocol (unenhanced, dynamic contrast material-enhanced, and 10-minute delayed CT) was used in 314 consecutive patients (201 women, 113 men; mean age, 63.6 years) for the period from January 2006 through February 2009. The mean adrenal attenuation during all three CT phases was measured by two readers, and the relative percentage washout (RPW) and absolute percentage washout (APW) values were calculated. APW and RPW receiver operating characteristic (ROC) analysis was performed to evaluate the strength of the tests. There were 323 adrenal lesions (213 left, 110 right) consisting of 307 adenomas and 16 nonadenomas. The sensitivity, specificity, and accuracy for the RPW test at a washout threshold of 50% were 55.7%, 100%, and 57.9%, respectively; at 40% were 76.9%, 93.7%, and 77.7%; and at 35% were 81.4%, 93.7%, and 82.0%. The sensitivity, specificity, and accuracy for the APW test at a 60% threshold were 52.1%, 93.3%, ...Continue Reading

References

Mar 10, 1998·AJR. American Journal of Roentgenology·M KorobkinF Londy
Jul 2, 1998·AJR. American Journal of Roentgenology·G W BolandP R Mueller
Oct 24, 2000·AJR. American Journal of Roentgenology·E M CaoiliN R Dunnick
Feb 28, 2002·Radiology·Elaine M CaoiliKartik I Raghupathi
Jan 20, 2005·Surgery·Andrea FrillingChristoph Broelsch
Sep 30, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Suman JanaM Donald Blaufox
Jun 28, 2006·Radiology·Peter F HahnGiles W L Boland
Mar 9, 2007·International Journal of Clinical Practice·S-J HanS-K Lim
Sep 21, 2007·Journal of Computer Assisted Tomography·Byung Kwan ParkJoon Young Choi

❮ Previous
Next ❯

Citations

Nov 6, 2010·Abdominal Imaging·Giles W L Boland
Sep 29, 2011·Langenbeck's Archives of Surgery·Barney Harrison
Nov 15, 2011·Hormones & Cancer·Désirée DeandreisEric Baudin
Jul 19, 2013·Journal of Computer Assisted Tomography·Ashkan A MalayeriKatarzyna J Macura
Jan 30, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·N J KhatiA M Schwartz
Jul 21, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S J Swensen
Jul 14, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·W W Mayo-SmithM J Lee
Feb 28, 2002·Radiology·Elaine M CaoiliKartik I Raghupathi
Jun 28, 2006·Radiology·Peter F HahnGiles W L Boland
Jun 24, 2006·AJR. American Journal of Roentgenology·James M A SlatteryGiles W Boland
Jan 23, 2010·AJR. American Journal of Roentgenology·Frank H MillerPaul Nikolaidis
May 22, 2010·AJR. American Journal of Roentgenology·Michael A BlakeGiles W Boland
Nov 1, 2012·AJR. American Journal of Roentgenology·Tobias HeyeDaniel T Boll
Apr 5, 2000·AJR. American Journal of Roentgenology·E M RemerM E Baker
Oct 24, 2000·AJR. American Journal of Roentgenology·E M CaoiliN R Dunnick
Feb 21, 2004·AJR. American Journal of Roentgenology·Alfred StadlerBruno Niederle
Apr 21, 2012·Radiology·Akshay K SaxenaUjjwal Gorsi
Apr 25, 2014·AJR. American Journal of Roentgenology·Jung Min SeoChan Kyo Kim
Apr 16, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Shaunagh McDermottMichael A Blake
Apr 11, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Subramanian KannanAmir H Hamrahian
May 27, 2014·The Surgical Clinics of North America·Peter J Mazzaglia
May 27, 2014·The Surgical Clinics of North America·Ryaz ChagparEren Berber
Apr 14, 2012·Radiologic Clinics of North America·Myles TaffelFrank H Miller
Feb 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·S McDermottM A Blake
Jul 15, 2015·Journal of Endocrinological Investigation·A StiglianoM Terzolo
May 17, 2011·Radiologic Clinics of North America·Giles W L Boland
Nov 28, 2015·Surgical Oncology Clinics of North America·Azadeh A Carr, Tracy S Wang
Jul 19, 2012·Journal of Magnetic Resonance Imaging : JMRI·Evan S Siegelman
Nov 7, 2015·Seminars in Roentgenology·Anil T TanerEvan S Siegelman
Apr 14, 2016·AJR. American Journal of Roentgenology·Robert W GarrettStewart G Albert
Feb 28, 2015·International Journal of Endocrinology·Nathalie LaunayPaul Legmann
Nov 22, 2016·Diagnostics·Iosif A MendichovszkyFiona J Gilbert
Feb 23, 2017·AJR. American Journal of Roentgenology·Nicola Schieda, Evan S Siegelman
Apr 13, 2017·AJR. American Journal of Roentgenology·Cristina MosconiRenato Pasquali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.