Oct 19, 2019

Incidental Brain MRI Findings in Children: A Systematic Review and Meta-Analysis

AJNR. American Journal of Neuroradiology
V Dangouloff-RosO Naggara

Abstract

The detection of incidental findings on children's brain MR imaging poses various practical issues because the life-long implications of such findings may be profound. Our aim was to assess the prevalence and characteristics of incidental brain MR imaging findings in children. Electronic databases (PubMed, EMBASE, and Cochrane) were searched for articles published between 1985 to July 2018, with the following search terms: "incidental," "findings," "brain," "MR imaging." Inclusion criteria were the following: 1) patients younger than 21 years of age, 2) healthy children without any clinical condition, 3) MR images obtained with at least a 1.5T magnet, 4) original articles, and 5) a methodologic quality score of ≥10. Two observers independently extracted data and assessed data quality and validity. The number and type of incidental findings were pooled. Heterogeneity was assessed using the Cochran Q statistic and the I2 statistic. Seven studies were included, reporting 5938 children (mean age, 11.3 ± 2.8 years). Incidental findings were present in 16.4% (99% CI, 9.8-26.2; Q = 117.5, I2= 94.9%) of healthy children, intracranial cysts being the most frequent (10.2%, 99% CI, 3.1-28.5; Q = 306.4, I2 = 98.0%). Nonspecific white matte...Continue Reading

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Mentioned in this Paper

Study
Meta Analysis (Statistical Procedure)
Follow-up
Magnetic Resonance Imaging
Stratification
Brain
PubMed
Intracranial
Neoplasms, Intracranial
Brain Neoplasms

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