PMID: 7538693Jan 1, 1995Paper

Incidental carcinoma of the prostate

Seminars in Surgical Oncology
G van AndelT M de Reijke

Abstract

Transrectal ultrasonography (TRUS), digital rectal examination (DRE), and quantification of serum prostate-specific antigen (PSA) are accepted and evaluated methods for detecting prostate cancer. Positive predictive values (PPV) of DRE and TRUS are low, and only slightly enhanced when used in combination with PSA. PSA lacks sufficient sensitivity and specificity to be used alone as a screening test for prostate cancer. The parameters PSA-density and PSA-velocity make PSA a better tumor marker, but they are not reliable on an individual basis. Age-specific reference ranges have the potential to make PSA a more sensitive tumor marker for men less than 60 years of age and a more specific one for men beyond 60 years. With currently available diagnostic methods approximately 10% of patients undergoing transurethral or open resection of the prostate for presumed benign prostatic hyperplasia will have carcinoma detected in the histologic material. In 392 patients successively treated in our clinic for presumed BPH and thoroughly investigated to exclude prostatic carcinoma (DRE, TRUS, biopsy when PSA > 4 ng/ml or PSA-D > 0.15), the tumor was found incidentally in 4%. Another finding in this study was the detection of prostatic carcinom...Continue Reading

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Citations

Nov 28, 2009·Pathology Oncology Research : POR·Sven GuniaAndreas Erbersdobler
Apr 29, 1998·Clinical Biochemistry·P S BuntingV Goel
Feb 15, 2001·The Journal of Urology·F D GillilandC R Key
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Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·P TuohimaaT Ylikomi
Nov 10, 2012·Clinical Genitourinary Cancer·Masaru Morita, Takeshi Matsuura

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