PMID: 29104281Nov 7, 2017Paper

Incidental Finding of Cryptococcus on Prostate Biopsy for Prostate Adenocarcinoma Following Cardiac Transplant: Case Report and Review of the Literature

The American Journal of Case Reports
Sujal I ShahShilpa Rungta

Abstract

BACKGROUND Cryptococcus is the third most common invasive fungal organism in immunocompromised patients, including transplant patients, and usually involves the central nervous system and lungs, with a median time to infection of 25 months. We report a case of Cryptococcus of the prostate gland, found as an incidental finding on prostate biopsy for prostate adenocarcinoma, four months following cardiac transplantation. CASE REPORT A 62-year-old male African-American who had a cardiac transplant four months previously, underwent a six-core prostate biopsy for a two-year history of increasing prostate-specific antigen (PSA) levels, and a recent history of non-specific urinary tract symptoms. A prostatic adenocarcinoma, Gleason grade 4+4=8, was diagnosed on histopathology, and 'foamy' cells were seen in the biopsies. Histochemical stains, including Grocott methenamine silver (GMS), and periodic acid-Schiff (PAS) showed abundant round and oval 5-7 µm diameter fungal elements; mucicarmine highlighted the fungal polysaccharide capsule, diagnostic for Cryptococcus. Cryptococcal antigen detection was made by the latex agglutination test and cultures. We reviewed the literature and found 70 published cases (from 1946-2008) of Cryptococc...Continue Reading

Citations

Jun 24, 2020·The Prostate·David J EpsteinJonathan I Epstein
Dec 14, 2019·BMC Infectious Diseases·Lijun XuBiao Zhu
Feb 15, 2019·Clinical Nuclear Medicine·Ling WangKun Tang
Jan 1, 2022·International Journal of Surgical Pathology·Atsuko Takada-OwadaKazuyuki Ishida

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