Incidental Findings on Coronary Computed Tomography Angiography in Human Immunodeficiency Virus (HIV)-Positive and HIV-Negative Persons

Open Forum Infectious Diseases
Sara ReinschmidtSwiss HIV Cohort Study

Abstract

Incidental findings on coronary computed tomography angiography (CCTA) have a great impact on the benefits and costs of testing for cardiovascular disease. The number of incidental findings might be increased in human immunodeficiency virus (HIV)-positive individuals compared with the general population. Data are limited regarding the association between incidental findings and HIV infection. We assessed the prevalence and factors associated with incidental findings among HIV-positive and HIV-negative participants ≥45 years undergoing CCTA. Logistic regression was performed to evaluate the factors associated with incidental findings in the HIV-positive and HIV-negative groups. For the analysis of the HIV effect, a propensity score-matched dataset of HIV-positive/HIV-negative participants was used. We included 553 participants, 341 with and 212 without HIV infection. Incidental findings were observed in 291 of 553 (53%) patients. In 42 of 553 (7.6%) participants, an incidental finding resulted in additional workup. A malignancy was diagnosed in 2 persons. In the HIV-positive group, age (1.31 per 5 years, 1.10-1.56) and smoking (2.29, 1.43-3.70) were associated with incidental findings; in the HIV-negative group, age (1.26, 1.01-...Continue Reading

References

Apr 9, 2004·Journal of Thoracic Imaging·Jeffrey G SchraginCarl R Fuhrman
Apr 17, 2008·Archives of Internal Medicine·Jeremy R BurtUNKNOWN Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology (ADVANCE) Study
Dec 2, 2009·International Journal of Epidemiology·UNKNOWN Swiss HIV Cohort StudyPatrick Francioli
Dec 4, 2010·BMC Research Notes·Paul Wx FoleyFrancisco Leyva
Jan 20, 2012·HIV Medicine·M HuberUNKNOWN Swiss HIV Cohort Study Group
Oct 25, 2013·Lancet·Steven G DeeksDiane V Havlir
Jan 18, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Line D RasmussenNiels Obel

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