Incidental prostate cancer at radical cystoprostatectomy: implications for apex-sparing surgery

BJU International
Georgios GakisArnulf Stenzl

Abstract

To analyse retrospectively the clinicopathological features of incidental prostate cancer in patients undergoing radical cystoprostatovesiculectomy (RCP) for invasive bladder cancer, as recent studies suggest that prostatic apex-sparing surgery in patients undergoing RCP improves urinary continence and erectile function after surgery, but in those with incidental prostate cancer, leaving the apical region endangers the oncological outcome. From 2004 to 2007, at our institution, 95 men had RCP for invasive bladder cancer. We reviewed their clinicopathological variables, especially apical involvement, and the course of prostate-specific antigen (PSA) levels before and after surgery. We compared clinically significant and insignificant prostate cancers. Of the 95 patients, 26 had incidental prostate cancer (mean age 68 years, range 53-80) on definitive histological examination. The mean (sd, range) preoperative PSA level in all 26 men was 3.6 (0.8, 0.2-14) ng/mL, but six of the 26 patients had preoperative PSA levels of >4 ng/mL and one other had suspicious findings on a digital rectal examination. Involvement of the apex was histologically confirmed in seven of the 26 patients (27%), including four with significant prostate cance...Continue Reading

References

Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P SteinD G Skinner
Jun 18, 2004·The Journal of Urology·G MutoC Giona
May 3, 2005·The Urologic Clinics of North America·Richard E Hautmann, John P Stein
May 3, 2005·The Urologic Clinics of North America·John P Stein, Donald G Skinner
Mar 7, 2006·World Journal of Urology·John P Stein, Donald G Skinner
Apr 20, 2006·Journal of the National Cancer Institute·Ian M ThompsonCharles A Coltman
Jan 19, 2007·Diagnostic Cytopathology·Kien T MaiHatim Al-Maghrabi
May 26, 2007·World Journal of Urology·Udo NageleMarkus A Kuczyk
Aug 11, 2007·European Urology·Joseph A PettusBernard H Bochner
Feb 5, 2008·Urology·Y Mark Hong, Kevin R Loughlin
Jul 16, 2008·European Urology·Karl-Dietrich SievertArnulf Stenzl
Jan 23, 2009·European Urology·Arnulf StenzlJ Alfred Witjes

❮ Previous
Next ❯

Citations

Jan 27, 2012·Der Urologe. Ausg. A·A HeidenreichD Pfister
Feb 12, 2013·World Journal of Urology·Georgios Gakis, Arnulf Stenzl
Jul 10, 2012·International Urology and Nephrology·M AlsinnawiJ A Thornhill
Oct 31, 2013·Annals of Surgical Oncology·Géraldine PignotUNKNOWN Oncologic Committee of the French Association of Urology
Jul 22, 2011·World Journal of Surgical Oncology·Berna Aytac, Hakan Vuruskan
Aug 25, 2012·European Urology·Georgios GakisUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Mar 6, 2012·Actas urologicas españolas·A StenzlUNKNOWN European Association of Urology
Apr 2, 2011·European Urology·Arnulf StenzlUNKNOWN European Association of Urology (EAU)
Feb 6, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Stephan BuseAxel Haferkamp
Jan 22, 2013·Scandinavian Journal of Urology·Georgios GakisMarkus Renninger
Nov 30, 2013·The Journal of Urology·Laura S MertensSimon Horenblas
Dec 29, 2012·Journal of the National Cancer Institute. Monographs·Gurdarshan S Sandhu, Gerald L Andriole
Oct 4, 2017·Japanese Journal of Clinical Oncology·Toshikazu TanakaTakahiro Yoneyama
Oct 2, 2014·Virchows Archiv : an International Journal of Pathology·C WetterauerC A Rentsch
Aug 17, 2017·Nature Reviews. Urology·Antonio Lopez-BeltranRodolfo Montironi
Jan 14, 2017·Genome Biology·Kamilla MundbjergGangning Liang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.