PMID: 40686Oct 1, 1979

Incipient germ cell tumor in a cryptorchid testis

Cancer
S DormanG W Leadbetter

Abstract

A 13-year-old male who had bilateral cryptorchid testes since birth underwent testicular biopsies and subsequent left orchiectomy following a diagnosis of malignant germ cell tumor. No tumor mass was noted although the malignant cells were seen within the seminiferous tubules and the interstitium. Five recorded cases of in-situ or incipient germ cell neoplasms of the testes are reviewed; three were infertile, another had a cryptorchid testis, and the fifth was both infertile and cryptorchid. Two of these patients have developed frank carcinoma, which would suggest that the process represents an early phase of invasive germ cell neoplasia.

References

Dec 1, 1982·European Journal of Pediatrics·E Hedinger
Jan 1, 1987·International Urology and Nephrology·M HornákD Ondrus
Jun 22, 2005·Virchows Archiv : an International Journal of Pathology·F E von EybenRolf Inge Skotheim
Aug 1, 1988·Journal of Pediatric Surgery·L CoxD Zacks
Aug 19, 2004·The American Journal of Surgical Pathology·John D HenleyThomas M Ulbright
Apr 1, 1994·British Journal of Urology·M C ParkinsonM C Pike
May 1, 1989·British Journal of Urology·H OzenD Remzi
Feb 1, 1987·International Journal of Andrology·H von der MaaseN E Skakkebaek
Aug 1, 1992·Cancer·P Mikulowski, J Oldbring
Jan 1, 1985·Acta Radiologica. Oncology·O Dahl
Sep 1, 1985·The Journal of Urology·A Nilsson, S Nilsson
Dec 1, 1981·The Journal of Urology·F E von EybenC Busch
Mar 1, 1984·The Journal of Urology·K E MufflyP J Gardner

Citations

Feb 1, 1976·AJR. American Journal of Roentgenology·M A BatataH Grabstald
Mar 1, 1975·Urology·J M DeCenzo, G W Leadbetter
Sep 9, 1972·Lancet·N E Skakkebaek
Sep 1, 1974·The Journal of Urology·G G GehringD M Woodhead
Feb 1, 1967·Southern Medical Journal·J A Dow, F K Mostofi
Mar 1, 1967·The Journal of Urology·B L Altman, M Malament
Jun 1, 1954·The Journal of Urology·J N ROBINSON, E T ENGLE
Jun 1, 1954·The Journal of Urology·J S GROVE

Related Concepts

Benign Neoplasm of Testis
Cryptorchidism
Neoplasm of Uncertain or Unknown Behavior of Testis
Interstitium
Neoplasms
Germ Cell Tumor
Cancer, Embryonal and Mixed
Neoplastic Disease
Inferior Colliculus
Testis

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.