PMID: 2484732Oct 23, 1989Paper

Inclusion bodies in motor cortex and brainstem of patients with motor neurone disease are detected by immunocytochemical localisation of ubiquitin

Neuroscience Letters
J LoweR J Mayer

Abstract

Histological sections of cerebral motor cortex, brainstem, and spinal cord from 10 cases of clinically diagnosed motor neurone disease (MND) and 10 control cases were examined by conventional histology and immunocytochemical methods to localise ubiquitin. Intracytoplasmic inclusion bodies were identified in motor neurones of hypoglossal nuclei and appeared specific for MND. Similar inclusions were found in both large pyramidal cells and small neurones in the motor cortex, and were restricted to 4 cases having the amyotrophic lateral sclerosis form of MND with severe degeneration of corticospinal tracts. As reported in earlier studies, cellular inclusion bodies were identified in motor neurones of spinal cord from cases of MND but not in control material. Ubiquitin inclusions in motor neurones appear to be markers for the degenerative process causing neuronal loss in MND and there appears to be a close association between the anatomical location of inclusions and clinical manifestations of disease.

References

Feb 23, 1989·Nature·J M Gallo, B H Anderton
Jan 1, 1989·Neuropathology and Applied Neurobiology·J LoweR J Mayer
Jul 31, 1989·Neuroscience Letters·P HeggieR J Mayer
Nov 11, 1988·Neuroscience Letters·P N LeighD M Power
Sep 1, 1987·Archives of Gerontology and Geriatrics·K MoritaM Namba

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Citations

Jul 1, 1994·Journal of the Neurological Sciences·J Lowe
Jun 13, 1991·Biochimica Et Biophysica Acta·R J MayerJ Lowe
Dec 25, 2003·Early Human Development·Toshiko SawaguchiAndre Kahn
May 22, 2003·Neuroscience Letters·Yuji MizunoKoichi Okamoto
Apr 1, 1996·Journal of Clinical and Experimental Neuropsychology·M J StrongH A Leeper
Jan 1, 1993·Brain Pathology·J LoweM Landon
Oct 20, 1998·Annals of Neurology·L Averbuch-HellerJ A Büttner-Ennerver
Sep 21, 2010·Journal of the Neurological Sciences·Takeshi WatanabeSeiitsu Ono
Mar 21, 2009·Journal of Neuroscience Research·Miranda W Richter, A Jane Roskams
Nov 1, 1992·Journal of Neurobiology·L M Schwartz
Apr 1, 1991·The Journal of Pathology·R J MayerM Landon
May 27, 2016·Biomolecular Concepts·Daichi Morimoto, Masahiro Shirakawa
Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T YamadaP L McGeer
Mar 3, 2004·Journal of Neuropathology and Experimental Neurology·Caterina BendottiAntonio Migheli

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