Inclusion of dosimetric data as covariates in toxicity-related radiogenomic studies : A systematic review

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Noorazrul YahyaFuad Ismail

Abstract

This systematic review evaluates the completeness of dosimetric features and their inclusion as covariates in genetic-toxicity association studies. Original research studies associating genetic features and normal tissue complications following radiotherapy were identified from PubMed. The use of dosimetric data was determined by mining the statement of prescription dose, dose fractionation, target volume selection or arrangement and dose distribution. The consideration of the dosimetric data as covariates was based on the statement mentioned in the statistical analysis section. The significance of these covariates was extracted from the results section. Descriptive analyses were performed to determine their completeness and inclusion as covariates. A total of 174 studies were found to satisfy the inclusion criteria. Studies published ≥2010 showed increased use of dose distribution information (p = 0.07). 33% of studies did not include any dose features in the analysis of gene-toxicity associations. Only 29% included dose distribution features as covariates and reported the results. 59% of studies which included dose distribution features found significant associations to toxicity. A large proportion of studies on the correlati...Continue Reading

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Citations

Sep 11, 2020·European Journal of Cancer Care·Noorazrul Yahya, Hanani A Manan
Oct 12, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Noorazrul Yahya, Hanani Abdul Manan
Aug 7, 2021·Brain Sciences·Hanani Abdul Manan, Noorazrul Yahya

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