Inclusion of emergency department patients in early stages of sepsis in a quality improvement programme has the potential to improve survival: a prospective dual-centre study

Emergency Medicine Journal : EMJ
Bas de GrootDouwe Rijpsma

Abstract

Sepsis quality improvement programmes typically focus on severe sepsis (ie, with acute organ failure). However, quality of ED care might be improved if these programmes included patients whose progression to severe sepsis could still be prevented (ie, infection without acute organ failure). We compared the impact on mortality of implementing a quality improvement programme among ED patients with a suspected infection with or without acute organ failure. This prospective observational study among ED patients hospitalised with suspected infection was conducted in two hospitals in the Netherlands. After stratification by sepsis category (with or without organ failure), in-hospital mortality was compared between a full compliance (all quality performance measures achieved) and an incomplete compliance group. Multivariable logistic regression analysis was used to quantify the impact of full compliance on in-hospital mortality, adjusting for disease severity, disposition and hospital. There were 1732 ED patients and 130 deaths. Full compliance was independently associated with approximately two-thirds reduction in the odds of hospital mortality (adjusted OR of 0.30 (95% CI 0.19 to 0.47), which was similar in patients with and without...Continue Reading

References

Jun 3, 1999·Journal of Accident & Emergency Medicine·M W Cooke, S Jinks
Apr 19, 2007·Critical Care Medicine·Donald B ChalfinUNKNOWN DELAY-ED study group
Dec 26, 2007·Critical Care Medicine·R Phillip DellingerUNKNOWN World Federation of Societies of Intensive and Critical Care Medicine
May 22, 2008·JAMA : the Journal of the American Medical Association·Ricard FerrerUNKNOWN Edusepsis Study Group
Aug 22, 2009·Chest·Anand KumarUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock Database Research Group
Apr 8, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Seth W GlickmanEmanuel P Rivers
Nov 3, 2010·Emergency Medicine Journal : EMJ·Ron DanielsClare Galvin
Nov 26, 2010·Critical Care Medicine·Michael D HowellNathan I Shapiro
Oct 20, 2011·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Bas de GrootAlice Vis
Aug 16, 2012·BMJ Quality & Safety·Gregg S MeyerGordon C Hunt
May 3, 2013·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Annemieke J M UittenbogaardBas de Groot
Jan 5, 2014·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Marcus HortmannMichael Christ
Mar 29, 2014·Critical Care Medicine·Arthur R H van ZantenUNKNOWN Netherlands Patient Safety Agency Sepsis Expert Group

❮ Previous
Next ❯

Citations

Jan 18, 2018·Emergency Medicine Australasia : EMA·Amith ShettyJonathan Iredell
Dec 3, 2020·Arquivos de neuro-psiquiatria·Aroldo BacellarOsvaldo José Moreira do Nascimento
Dec 22, 2021·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Bas de GrootChristian H Nickel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.