Incobotulinum Toxin-A Improves Post-Surgical and Post-Radiation Pain in Cancer Patients

Toxins
Rezvan RostamiBahman Jabbari

Abstract

Cancer patients who undergo surgery or radiation can develop persistent focal pain at the site of radiation or surgery. Twelve patients who had surgery or radiation for local cancer and failed at least two analgesic medications for pain control were prospectively enrolled in a research protocol. Patients were injected up to 100 units of incobotulinum toxin A (IncoA) intramuscularly or subcutaneously depending on the type and location of pain (muscle cramp or neuropathic pain). Two patients passed away, one dropped out due to a skin reaction and another patient could not return for the follow up due to his poor general condition. All remaining 8 subjects (Age 31-70, 4 female) demonstrated significant improvement of Visual Analog Scale (VAS) (3 to 9 degrees, average 3.9 degrees) and reported significant satisfaction in Patients' Global Impression of Change scale (PGIC) (7 out of 8 reported the pain as much improved). Three of the 8 patients reported significant improvement of quality of life.

Associated Clinical Trials

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Citations

Mar 23, 2017·The Journal of Headache and Pain·Giorgio SandriniStefano Tamburin
Aug 25, 2017·Toxins·JungHyun Park, Hue Jung Park
Jan 18, 2020·Toxins·Shivam Om Mittal, Bahman Jabbari
Mar 28, 2020·Journal of the American Geriatrics Society·Russell K Portenoy
Jun 13, 2020·Current Pain and Headache Reports·Alexander CapucoOmar Viswanath
Aug 28, 2020·Frontiers in Neurology·Gabriella EgeoPiero Barbanti
Dec 25, 2021·Applied Microbiology and Biotechnology·Tomasz GrendaKrzysztof Kwiatek

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Clinical Trials Mentioned

NCT01931865

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