Incobotulinumtoxin A for Sialorrhea in Neurological Disorders: A Real-Life Experience

Toxins
Javier Martínez-PolesAraceli Alonso-Canovas

Abstract

Botulinum toxin type A is one of the most useful treatments of sialorrhea in neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were treated with infiltrations of inco-A into both parotid glands. The severity of sialorrhea was evaluated by the Drooling Severity Scale (DSS), and the Drooling Frequency Scale (DFS). Patients' perceptions of clinical benefit were recorded via the Patient Global Impression of Improvement (PGI-I) scale. Following treatment, there was a significant difference in both the DFS and the DSS (p < 0.001). Clinical benefits on the basis of the PGI-I were present in up to 90% of patients.

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Jul 19, 2019·Journal of Clinical Nursing·Li Ping VarleyMartina Gooney
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Aug 28, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ya-Chien YuYi-Chun Kuan

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