Dec 30, 2015

Incoherent feedforward motifs as immune change detectors

BioRxiv : the Preprint Server for Biology
Eduardo Sontag

Abstract

We speculate that incoherent feedforward loops may be phenomenologically involved in self/nonself discrimination in immune-infection and immune-tumor interactions, acting as "change detectors". In turn, this may result in logarithmic sensing (Weber phenomenon) and even scale invariance (fold-change detection).

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Mentioned in this Paper

Protein Domain
Tumor Immunity
Tolerance Induction to Nonself Antigen
Hemoglobin M-Saskatoon

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