Incomplete editing of rps12 transcripts results in the synthesis of polymorphic polypeptides in plant mitochondria

The Plant Cell
C G PhreanerR M Mulligan

Abstract

C-to-U editing causes specific nucleotide changes in plant mitochondrial nRNAs that are required for the restoration of the evolutionarily conserved amino acid sequence. Transcripts for the ribosomal protein S12 gene (rps12) have six C-to-U editing sites and are highly heterogeneous as a result of incomplete editing. immunological analysis demonstrated that unedited or partially edited transcripts as well as edited mRNAs are translated. The edited rps12 translation products accumulate as ribosomal subunits, but the unedited rps12 translation products are present as unassembled subunits and are not detected in the ribosomes. Thus, gene expression is polymorphic as a result of incomplete C-to-U editing, and aberrant polypeptides are present from the translation of these mRNAs. However, because only the edited translation products accumulate in mitochondrial ribosomes, the overall expression of rps12 is rendered coherent by the selection

References

Nov 1, 1991·Current Genetics·W SchusterA Brennicke
Dec 22, 1989·Science·R HieselA Brennicke
Oct 19, 1989·Nature·P S Covello, M W Gray
Jul 1, 1993·Plant Molecular Biology·S Y Rish, A Breiman

❮ Previous
Next ❯

Citations

May 5, 2009·Plant Molecular Biology·Inga HinrichsenFrank Kempken
Apr 9, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·P Giegé, A Brennicke
May 9, 2003·Nucleic Acids Research·Anne-Laure Chateigner-Boutin, Maureen R Hanson
Feb 22, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stefan Binder, Axel Brennicke
May 21, 2011·Science·Mingyao LiVivian G Cheung
Nov 28, 2013·Annual Review of Genetics·Mizuki TakenakaAxel Brennicke
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·P. LeonS. Mackenzie
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kenji OkudaToshiharu Shikanai
Mar 8, 2008·Mitochondrion·Mizuki TakenakaAxel Brennicke
Jun 16, 2006·The Plant Journal : for Cell and Molecular Biology·Daniil VerbitskiyAxel Brennicke
May 26, 2010·The Plant Journal : for Cell and Molecular Biology·Tzu-Ying SungMing-Hsiun Hsieh
Oct 1, 2011·Wiley Interdisciplinary Reviews. RNA·Anne-Laure Chateigner-Boutin, Ian Small
Oct 31, 2016·Trends in Plant Science·Tao SunMaureen R Hanson
Mar 4, 2017·Genetics and Molecular Biology·Nureyev F RodriguesRogério Margis
Dec 20, 2017·Plant Methods·Muhammad Waqar HameedJoost Thomas van Dongen
Oct 21, 2019·The Plant Journal : for Cell and Molecular Biology·Ian D SmallOren Ostersetzer-Biran
Oct 17, 2017·The Plant Journal : for Cell and Molecular Biology·Michael F DiazR Michael Mulligan
Jul 16, 2016·PLoS Genetics·Prakitchai Chotewutmontri, Alice Barkan
Jun 19, 1998·Biochimica Et Biophysica Acta·A G RasmussonL Grohmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.