Incomplete follow-up of positive HPV tests: overview of randomised controlled trials on primary cervical screening.

British Journal of Cancer
Matejka Rebolj, Elsebeth Lynge

Abstract

It has been suggested that adjustment for incomplete compliance with follow-up in women with positive human papillomavirus (HPV) tests would be appropriate for estimating the true sensitivity of cervical screening with HPV testing. We assessed the compliance and its impact on > or =CIN3 detection in all eight randomised controlled trials (RCT) with published baseline-round data. We extracted data on recommended follow-up procedures, follow-up compliance, and > or =CIN3 detection for both arms of each RCT, and assessed their correlation. Compliance with a direct referral for colposcopy was around 90% in all RCTs, whereas compliance with repeated testing among HPV-positive/cytology-negative women was around 60% in three RCTs and 73% in one RCT. Detection of > or =CIN3 was significantly increased in two out of six RCTs with reported data. The correlation between compliance with follow-up in HPV-positive women and relative > or =CIN3 detection was 0.48 (P=0.33). There is at present scant evidence to support the view that the measured sensitivity of HPV screening is a simple reflection of compliance with follow-up. Adjustment of measured cervical intraepithelial neoplasia detection on the basis of compliance data may not always be j...Continue Reading

References

Sep 10, 2005·American Journal of Obstetrics and Gynecology·Kristina ElfgrenUNKNOWN Swedescreen Study Group
Jun 8, 2006·Journal of the National Cancer Institute·Guglielmo RoncoUNKNOWN New Technologies for Cervical Cancer Working Group
Jul 4, 2006·The Lancet Oncology·Guglielmo RoncoUNKNOWN New Technologies for Cervical Cancer screening Working Group
Oct 19, 2007·The New England Journal of Medicine·Marie-Hélène MayrandUNKNOWN Canadian Cervical Cancer Screening Trial Study Group
Oct 19, 2007·The New England Journal of Medicine·Pontus NauclerJoakim Dillner
Feb 6, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Laura Kotaniemi-TalonenPekka Nieminen
Mar 28, 2008·Journal of the National Cancer Institute·Guglielmo RoncoUNKNOWN New Technologies for Cervical Cancer Screening Working Group
Sep 16, 2008·International Journal of Cancer. Journal International Du Cancer·Laura Kotaniemi-TalonenMatti Hakama
Jan 15, 2009·Journal of the National Cancer Institute·Pontus NauclerJoakim Dillner
Apr 3, 2009·The New England Journal of Medicine·Rengaswamy SankaranarayananKetayun A Dinshaw
Sep 1, 2009·The Lancet Oncology·Peter SasieniJack Cuzick
Nov 7, 2009·Health Technology Assessment : HTA·H C KitchenerUNKNOWN ARTISTIC Trial Study Group
Nov 12, 2009·Journal of the National Cancer Institute·Maarit LeinonenAhti Anttila
Jan 22, 2010·The Lancet Oncology·Guglielmo RoncoUNKNOWN New Technologies for Cervical Cancer screening (NTCC) Working Group

❮ Previous
Next ❯

Citations

Nov 29, 2014·Journal of Medical Screening·L PasqualeM Confortini
Feb 4, 2014·Journal of Medical Screening·Annarosa Del MistroUNKNOWN Veneto HPV-screening Working Group
Aug 3, 2011·Expert Review of Anticancer Therapy·Matejka ReboljJesper Bonde
Sep 14, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·M ReboljJ Bonde
Oct 19, 2020·International Journal of Cancer. Journal International Du Cancer·Leonardo I GreenUNKNOWN HPV Pilot Steering Committee

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cytopathology : Official Journal of the British Society for Clinical Cytology
A A T P BrinkC J L M Meijer
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Philip E CastlePatti E Gravitt
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Philip E CastleRobert D Burk
© 2021 Meta ULC. All rights reserved