Incomplete host immunity favors the evolution of virulence in an emergent pathogen

Science
Arietta E Fleming-DaviesDana M Hawley

Abstract

Immune memory evolved to protect hosts from reinfection, but incomplete responses that allow future reinfection may inadvertently select for more-harmful pathogens. We present empirical and modeling evidence that incomplete immunity promotes the evolution of higher virulence in a natural host-pathogen system. We performed sequential infections of house finches with Mycoplasma gallisepticum strains of various levels of virulence. Virulent bacterial strains generated stronger host protection against reinfection than less virulent strains and thus excluded less virulent strains from infecting previously exposed hosts. In a two-strain model, the resulting fitness advantage selected for an almost twofold increase in pathogen virulence. Thus, the same immune systems that protect hosts from infection can concomitantly drive the evolution of more-harmful pathogens in nature.

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References

Jun 4, 2002·Pediatrics·Susan HallMelinda Wharton
May 13, 2004·Journal of Wildlife Diseases·George V KolliasAndré A Dhondt
Jun 9, 2005·Journal of Mathematical Biology·M G M GomesC Rebelo
Aug 19, 2005·Journal of Wildlife Diseases·Keila V SydenstrickerGeorge V Kollias
May 8, 2007·Ecological Applications : a Publication of the Ecological Society of America·Christopher S JennelleJuan Carlos Senar
May 15, 2007·Avian Pathology : Journal of the W.V.P.A·André A DhondtChristopher S Jennelle
Jan 5, 2008·Molecular Ecology·Paul D Williams, Troy Day
May 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jacobus C de RoodeSonia Altizer
Jun 24, 2008·Journal of Theoretical Biology·Simeone MarinoDenise E Kirschner
Jan 14, 2009·Trends in Immunology·Miles P DavenportRuy M Ribeiro
Apr 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Camille BonneaudScott V Edwards
May 18, 2011·Cell Host & Microbe·Mihai G NeteaJos W M van der Meer
Jan 6, 2012·The American Naturalist·Paul David Williams
Jan 27, 2012·Evolution; International Journal of Organic Evolution·Erik E Osnas, Andrew P Dobson
Mar 9, 2013·The Journal of Infectious Diseases·William M GeislerEdward W Hook
Jun 1, 2013·PLoS Biology·Dana M HawleyAndré A Dhondt
Jul 12, 2013·Proceedings. Biological Sciences·Wesley M HochachkaIrby J Lovette
Apr 23, 2014·Journal of Evolutionary Biology·P D WilliamsA A Dhondt
Jul 28, 2015·PLoS Biology·Andrew F ReadVenugopal K Nair
Sep 15, 2015·Ecology Letters·Arietta E Fleming-DaviesGreg Dwyer
Aug 3, 2017·EcoHealth·Ariel E Leon, Dana M Hawley
Dec 16, 2017·Journal of Avian Biology·James S AdelmanDana M Hawley

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Citations

Aug 15, 2018·Journal of Evolutionary Biology·Daisy Elizabeth GatesMario Recker
Feb 9, 2019·Evolution; International Journal of Organic Evolution·Miguel A AcevedoBret D Elderd
May 30, 2019·Integrative and Comparative Biology·Amberleigh E Henschen, James S Adelman
Jan 24, 2020·Expert Review of Vaccines·Andrew S FliesRuth J Pye
Sep 30, 2018·Nature Reviews. Immunology·Maziar Divangahi
Dec 7, 2018·Frontiers in Genetics·Mikhail OrlovAnatoly Sorokin
Aug 14, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sarah GuthCara E Brook
Feb 15, 2019·Frontiers in Immunology·Andrew S Flies, Gregory M Woods
Aug 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Luc TardyCamille Bonneaud
Jul 2, 2020·Ecology and Evolution·María Teresa Reinoso-PérezAndré A Dhondt
Apr 7, 2021·The Journal of Animal Ecology·Wesley M HochachkaAndré A Dhondt
Sep 22, 2020·Trends in Parasitology·K M Barnett, David J Civitello

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