Incomplete recovery of erectile function in rat after discontinuation of dual 5-alpha reductase inhibitor therapy

The Journal of Sexual Medicine
Cetin Volkan OztekinWayne J G Hellstrom

Abstract

The association of 5-alpha reductase inhibitor (5ARI) therapy and sexual dysfunction has been reported. Some patients claim persistent erectile dysfunction despite long-term discontinuation of 5ARI treatment. The aim of this study was to assess erectile function after cessation of 5ARI therapy using a rat model. Twenty-six adult male Sprague-Dawley rats were randomized into three groups: (i) control (N = 10); (ii) 8-week dutasteride treatment (0.5 mg/rat/day, in drinking water, N = 8); and (iii) 6-week dutasteride treatment followed by a 2-week washout period (N = 8). The experiments were performed after 8 weeks from the initiation of treatment in all groups. In vivo erectile activity and in vitro contractile and relaxant responses of cavernosal smooth muscle were investigated. In vivo erectile activity (intracavernosal pressure [ICP]/mean arterial pressure [MAP] and total ICP) in treatment groups were significantly decreased compared with controls (ICP/MAP: P < 0.001 for 2.5 v, 5 v, and 7.5 v; total ICP: P < 0.001 for 5 v and P < 0.01 for 7.5 v). Acetylcholine-induced relaxations were diminished in treatment groups (P < 0.05). Relaxant responses to electrical field stimulation (EFS) were decreased in the 8-week treatment group...Continue Reading

References

Jul 17, 1992·Science·A L BurnettS H Snyder
Jul 31, 1990·Biochemical and Biophysical Research Communications·L J IgnarroJ Rajfer
May 1, 1987·Journal of Steroid Biochemistry·L MilewichA R Johnson
Aug 28, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·M Feelisch
May 4, 2005·Pharmacology & Therapeutics·Noboru TodaTomio Okamura
Dec 24, 2005·Asian Journal of Andrology·Louis J G Gooren, Farid Saad
Dec 19, 2008·The Journal of Sexual Medicine·Fikret ErdemirWayne J G Hellstrom
Mar 23, 2011·The Journal of Sexual Medicine·Michael S Irwig, Swapna Kolukula
Aug 13, 2011·The Journal of Sexual Medicine·Michael R PinskyWayne J G Hellstrom
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Xinhua ZhangMichael E Disanto
Feb 16, 2012·Prostate Cancer and Prostatic Diseases·F Azzouni, J Mohler

❮ Previous
Next ❯

Citations

Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Abdulmaged M Traish
May 20, 2015·Expert Opinion on Investigational Drugs·Kanika GuptaJeanny B Aragon-Ching
Jan 1, 2014·Sexual Medicine Reviews·Michael S Irwig
May 1, 2013·Sexual Medicine Reviews·Landon TrostWayne J G Hellstrom
Aug 25, 2015·Reviews in Endocrine & Metabolic Disorders·Abdulmaged M TraishMichael Zitzmann
Nov 5, 2016·Actas dermo-sifiliográficas·S Arias-Santiago, F M Camacho-Martínez
Jun 6, 2014·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Ozge UnSerap Gur
Mar 13, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Abdullah GulEge Can Serefoglu
Apr 15, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Michael S Irwig
Jun 9, 2015·Hormone Molecular Biology and Clinical Investigation·Abdulmaged M TraishAhmad Haider
Mar 24, 2020·The World Journal of Men's Health·Abdulmaged M Traish
Feb 9, 2020·Fertility and Sterility·Abdulmaged M Traish

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.