PMID: 11338713May 8, 2001Paper

Inconsistent detection of PrP in extraneural tissues of cats with feline spongiform encephalopathy

The Veterinary Record
S J RyderG R Pearson

Abstract

Feline spongiform encephalopathy (FSE), a transmissible spongiform encephalopathy or prion disease of cats, first reported in Great Britain in 1990, is believed to result from the consumption of food contaminated by the agent of bovine spongiform encephalopathy (BSE). The accumulation of PrP in non-neural tissues of cats diagnosed as suffering from FSE was investigated by immunohistochemistry. In the majority of the cats no disease-specific PrP was detected in lymphoid tissues. Small amounts of PrP were detected in the spleen of only two of 13 samples examined, in Peyer's patches of one of the two cases for which suitable material was available, but in the myenteric plexus of all four cats in which sections of intestine were examined. In addition PrP immunostaining was found in the kidney of all the cats with FSE whose kidneys were examined.

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Citations

Apr 12, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cyrus BettChristina J Sigurdson
Mar 3, 2004·Journal of Clinical Pathology·D A HiltonJ W Ironside
Jun 17, 2010·The Journal of Clinical Investigation·Christina J SigurdsonAdriano Aguzzi
Apr 5, 2008·Journal of Comparative Pathology·C J SigurdsonE A Hoover
Oct 12, 2004·Gene·Dominikus A LysekKurt Wüthrich
Dec 3, 2014·Virus Research·Patricia Aguilar-CalvoJuan María Torres
Sep 26, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Amir N HamirAllen L Jenny
Aug 30, 2008·Veterinary Pathology·B IuliniC Casalone
Oct 3, 2003·British Medical Bulletin·Christina J Sigurdson, Michael W Miller
Nov 30, 2004·Expert Review of Anti-infective Therapy·Larisa Cervenakova, Paul Brown
Apr 16, 2004·Australian Veterinary Journal·S Young, R F Slocombe
Jul 30, 2003·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Dominic Travis, Michele Miller
Sep 5, 2006·The Veterinary Record·Sílvia SisóPhilip Steele

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