PMID: 12957250Sep 6, 2003Paper

Incorporating clinical measurements of hypoxia into tumor local control modeling of prostate cancer: implications for the alpha/beta ratio

International Journal of Radiation Oncology, Biology, Physics
A E NahumJ Donald Chapman

Abstract

The recently obtained low value of approximately 1.5 for the alpha/beta of prostate cancer has led us to reexamine the optimal prostate tumor biology parameters, while taking into account everything known about the radiation response of prostate clonogens for use in a predictive dose-response model. Averages of the literature values of the alpha- and beta-inactivation coefficients for human prostate cancer cell lines were calculated. A robust tumor local control probability (TLCP) model was used that required average alpha and beta, as well as sigma(alpha), for the interpatient variation in single-hit killing (alpha). Median PO(2) values <or=1 mm Hg in the prostates of Fox Chase Cancer Center brachytherapy patients had been found in 21% of 115 cases. The oxygen enhancement ratios of 1.75 and 3.25 for alpha- and beta-inactivation, respectively, measured for tumor cells in vitro, were incorporated into the TLCP model, together with a clonogen density of approximately 10(5) cells/cm(3). Severe hypoxia and radioresistance were estimated for a proportion of tumors that was increased with PSA level. For asynchronous human prostate cell lines irradiated in air, alpha(mean) was 0.26 +/- 0.07 (standard error) Gy(-1), sigma(alpha) = 0.06...Continue Reading

References

Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·J Donald ChapmanR C Urtasun
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·H D SuitR Sedlacek
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·S L Tucker, H D Thames
May 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G G Steel, J H Peacock
Jul 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M WollinJ S Greenberger
Sep 1, 1985·International Journal of Radiation Oncology, Biology, Physics·B Fertil, E P Malaise
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J DeaconG G Steel
Nov 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Niemierko, M Goitein
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·David J Brenner
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·Gerald E HanksL Coia
May 20, 1998·International Journal of Radiation Oncology, Biology, Physics·R G StockJ K DeWyngaert
Jul 2, 1998·The Journal of Urology·T L DeWeeseW G Nelson
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·David J Brenner, E J Hall
Feb 3, 2000·International Journal of Radiation Oncology, Biology, Physics·C R KingD E Wazer
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·Beatriz Sánchez-Nieto, A E Nahum
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·J M Brown
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·C R King, Jack F Fowler
Oct 5, 2001·American Journal of Clinical Oncology·J Donald ChapmanY Matsumoto
Sep 5, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Iuliana Toma-DaşuJack F Fowler
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Jian Z WangX Allen Li
Mar 13, 2003·Physics in Medicine and Biology·P E LindsayJ J Battista
Mar 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eric M HorwitzGerald E Hanks
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Henk B Kal, Marion P R Van Gellekom

Citations

Jul 25, 2009·Australasian Physical & Engineering Sciences in Medicine·P Deb, A Fielding
Jul 4, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Víctor Macías, Albert Biete
Aug 24, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-M CossetF Eschwège
Oct 30, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·R AzzeroniRiccardo Calandrino
Jan 24, 2006·Preparative Biochemistry & Biotechnology·Kyoung-Soo ChoiJong Hoon Park
Feb 7, 2009·The Cancer Journal·Mark A RitterDaniel Petereit
Mar 31, 2012·Advances in Urology·Susan MassonAmit Bahl
Mar 28, 2013·Prostate Cancer·L Chinsoo ChoBrian Kavanagh
Jul 5, 2012·Medical Physics·S M OliveiraL Fernandes
Mar 8, 2013·Medical Physics·Seán Walsh, Wil van der Putten
Aug 4, 2006·The British Journal of Radiology·Jian Z WangNina A Mayr
Nov 28, 2007·The British Journal of Radiology·X Allen LiC A Lawton
Dec 17, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hans CrezeeH Petra Kok
Sep 1, 2012·International Journal of Radiation Oncology, Biology, Physics·J Donald Chapman, Colin J Gillespie
Nov 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Yixiang LiaoJay Burmeister
Jul 21, 2009·International Journal of Radiation Oncology, Biology, Physics·Albert TiongDavid Joseph
May 23, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·A Daşu
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Lourdes M GarciaG Peter Raaphorst
Feb 24, 2016·The British Journal of Radiology·Philip S BoonstraRafał Suwiński
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Jian Z Wang, X Allen Li
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Jian Z WangRobert D Stewart
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·Annette HaworthGillian M Duchesne
Apr 20, 2004·International Journal of Radiation Oncology, Biology, Physics·Rachel K BodeyGlenn D Flux
Mar 28, 2006·International Journal of Radiation Oncology, Biology, Physics·Dawn M CarnellPeter J Hoskin
Oct 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Alan PollackRobert A Price
May 10, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Riccardo ValdagniA E Nahum
Mar 26, 2013·Computer Methods and Programs in Biomedicine·Lanlan ZhangRalf O Floca
Aug 30, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Riccardo ValdagniClaudio Fiorino
May 11, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nora SundahlValerie Fonteyne
Oct 18, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-M Cosset, C Haie-Meder
Apr 9, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mauro IoriA E Nahum
Jul 11, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Guy SoeteGuy Storme
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan PollackMark K Buyyounouski
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Himu LukkaWinkle Kwan
Jun 12, 2004·Medical Physics·Marco CarlonePeter Raaphorst
Nov 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Z Jay ChenRavinder Nath
Jul 7, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·G C Morton
Apr 19, 2006·International Journal of Radiation Oncology, Biology, Physics·Emile N J T van LinAndries G Visser
Mar 13, 2008·Cancer Treatment Reviews·Laure MarignolDonal Hollywood
Jan 16, 2014·Journal of Applied Clinical Medical Physics·Aime M Gloi
Dec 11, 2014·Journal of Applied Clinical Medical Physics·Vanessa PanettieriJeremy L Millar
Apr 11, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Beatriz Sánchez-NietoFrancisco Sánchez-Doblado
Feb 1, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Olga SchimpfLutz Lüdemann
Jan 27, 2009·Technology in Cancer Research & Treatment·Panayiotis MavroidisNikos Papanikolaou
Nov 24, 2004·Physics in Medicine and Biology·David J CarlsonM Guerrero
Jun 12, 2004·Medical Physics·Maurizio MattiaBarbara Caccia
Aug 1, 2007·Physics in Medicine and Biology·Panayiotis MavroidisNikos Papanikolaou
Dec 12, 2007·BJU International·Marco van VulpenJeroen R J A van Moorselaar
Jun 24, 2005·Physics in Medicine and Biology·N SuchowerskaM Jackson
Jan 19, 2018·Mathematical Medicine and Biology : a Journal of the IMA·C BruniC Sinisgalli
Sep 24, 2005·Physics in Medicine and Biology·Iuliana Toma-DaşuMikael Karlsson
Mar 3, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vladimir AvkshtolEric M Horwitz
Aug 8, 2008·Acta Oncologica·Claudio FiorinoRiccardo Calandrino
Aug 10, 2011·Radiation Research·Robert D StewartDavid J Carlson
Oct 31, 2018·Frontiers in Physiology·Antonella BelfattoPietro Cerveri
Jun 22, 2013·Physics in Medicine and Biology·J JeongJ O Deasy
Aug 1, 2012·Expert Review of Anticancer Therapy·Peter VavassisMichael Yassa
May 19, 2006·Cancer Research·Soo-Yeon ParkYoung-Mee Park
Sep 14, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Jake C ForsterEva Bezak
Mar 7, 2021·Brachytherapy·Elisheva DonathDaniel Taussky

Related Concepts

Surface Radiotherapy
Cell Survival
Dioxygen
Probability
Malignant Neoplasm of Prostate
Radiation Tolerance
Radiobiology
Radiotherapy Dosage
Tumor Cells, Cultured
Cell Hypoxia

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Jian Z WangX Allen Li
International Journal of Radiation Oncology, Biology, Physics
C R King, C S Mayo
International Journal of Radiation Oncology, Biology, Physics
David J Brenner, E J Hall
© 2021 Meta ULC. All rights reserved