Incorporating partial shining effects in proton pencil-beam dose calculation

Physics in Medicine and Biology
Yupeng LiRadhe Mohan

Abstract

A range modulator wheel (RMW) is an essential component in passively scattered proton therapy. We have observed that a proton beam spot may shine on multiple steps of the RMW. Proton dose calculation algorithms normally do not consider the partial shining effect, and thus overestimate the dose at the proximal shoulder of spread-out Bragg peak (SOBP) compared with the measurement. If the SOBP is adjusted to better fit the plateau region, the entrance dose is likely to be underestimated. In this work, we developed an algorithm that can be used to model this effect and to allow for dose calculations that better fit the measured SOBP. First, a set of apparent modulator weights was calculated without considering partial shining. Next, protons spilled from the accelerator reaching the modulator wheel were simplified as a circular spot of uniform intensity. A weight-splitting process was then performed to generate a set of effective modulator weights with the partial shining effect incorporated. The SOBPs of eight options, which are used to label different combinations of proton-beam energy and scattering devices, were calculated with the generated effective weights. Our algorithm fitted the measured SOBP at the proximal and entrance ...Continue Reading

References

May 1, 1991·Medical Physics·P L PettiB A Ludewigt
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·P L Petti
Aug 1, 1996·Physics in Medicine and Biology·L HongM Urie
Aug 1, 1996·Physics in Medicine and Biology·T Bortfeld, W Schlegel
Oct 12, 2002·Physics in Medicine and Biology·Hanitra Szymanowski, Uwe Oelfke
Oct 1, 2003·Physics in Medicine and Biology·Hanne M KooyThomas Bortfeld
Feb 20, 2004·Journal of Bacteriology·Ulrike SamenDieter J Reinscheid
Oct 21, 2005·Physics in Medicine and Biology·Martin SoukupMarkus Alber
Mar 16, 2006·Cancer Investigation·Shannon M MacDonaldJay S Loeffler
Jul 20, 2007·Physics in Medicine and Biology·Wayne NewhauserRadhe Mohan

❮ Previous
Next ❯

Citations

Aug 17, 2012·Medical Physics·Wenhua CaoXiaodong Zhang
Oct 9, 2009·Medical Physics·Alfred SmithKoji Matsuda
Jan 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Xiaoning PanZhongxing Liao
Aug 30, 2008·International Journal of Radiation Oncology, Biology, Physics·Xiaodong ZhangZhongxing Liao
Jun 9, 2016·Australasian Physical & Engineering Sciences in Medicine·Toshiyuki ToshitoJun'etsu Mizoe
Jan 26, 2011·Physics in Medicine and Biology·Yupeng LiRadhe Mohan
Apr 14, 2016·Journal of Applied Clinical Medical Physics·Tianyu ZhaoEric E Klein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.