Incorporating the rotational setup uncertainty into the planning target volume margin expansion for the single isocenter for multiple targets technique

Practical Radiation Oncology
Jenghwa Chang

Abstract

The single isocenter for multiple targets (SIMT) technique has become a popular treatment approach for multiple brain metastases. However, the rotational error that is introduced is usually not considered in planning target volume (PTV) expansion. We have developed a statistical model that takes into account both translational and rotational uncertainties. In this study, we incorporated the rotational error into PTV margin expansion for the clinical use of the SIMT technique. In the statistical model, both translational and rotational errors are assumed to follow the 3-dimensional, independent, normal distribution with a zero mean and standard deviations of σS and σR, where σR = 0.01424σD (rotational uncertainty in degree)×dI ⇔ T (distance in mm from isocenter to target). Based on this model, we derived in this study the additional PTV margin, ∆M, that is required to maintain the same coverage probability when the rotational uncertainty is present as a function of MS (initial PTV margin), σD, and dI ⇔ T. The maximum allowable dI ⇔ T, C and σD, C were also calculated as a function of user-specified ∆Mc/MS, the fraction of MS below which the extra PTV margins can be ignored. Combined PTV margin, ME, and additional PTV margin, ∆M,...Continue Reading

References

Oct 20, 2009·International Journal of Radiation Oncology, Biology, Physics·Grant M ClarkJohn B Fiveash
Jul 7, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yimei HuangSamuel Ryu
Jul 17, 2015·JAMA Oncology·Hidefumi AoyamaUNKNOWN Japanese Radiation Oncology Study Group 99-1 (JROSG 99-1) Investigators
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Justin RoperAnees Dhabaan
Sep 12, 2016·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Jay MorrisonJustus Adamson

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Citations

Jul 23, 2019·Journal of Applied Clinical Medical Physics·Kang-Hyun AhnBulent Aydogan
Dec 4, 2019·Journal of Applied Clinical Medical Physics·Junjie MiaoJianrong Dai
Oct 30, 2020·Journal of Applied Clinical Medical Physics·Hisashi NakanoHidefumi Aoyama
Feb 8, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Allison N PalmieroDamodar Pokhrel
Apr 3, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes KraftNicolaus Andratschke
Jun 22, 2021·Journal of Applied Clinical Medical Physics·Hisashi NakanoHiroyuki Ishikawa
Jul 3, 2021·Journal of Applied Clinical Medical Physics·André Vinícius de CamargoRaphael Leonardo Cunha de Araújo

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