Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds

Journal of Controlled Release : Official Journal of the Controlled Release Society
Kwangsok KimMichael Hadjiargyrou

Abstract

The successful incorporation and sustained release of a hydrophilic antibiotic drug (Mefoxin, cefoxitin sodium) from electrospun poly(lactide-co-glycolide) (PLGA)-based nanofibrous scaffolds without the loss of structure and bioactivity was demonstrated. The morphology and density of the electrospun scaffold was found to be dependent on the drug concentration, which could be attributed to the effect of ionic salt on the electrospinning process. The drug release behavior from the electrospun scaffolds and its antimicrobial effects on Staphylococcus aureus cultures were also investigated. In all tested scaffolds, the maximum dosage of drug was released after 1 h of incubation in water at 37 degrees C. The usage of the amphiphilic block copolymer (PEG-b-PLA) reduced the cumulative amount of the released drug at earlier time points and prolonged the drug release rate at longer times (up to a 1-week period). The antibiotic drug released from these electrospun scaffolds was effective in their ability to inhibit Staphylococcus aureus growth (>90%). The combination of mechanical barriers based on non-woven nanofibrous biodegradable scaffolds and their capability for local delivery of antibiotics increases their desired utility in biome...Continue Reading

References

Sep 28, 1990·Science·R Langer
May 1, 1995·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E K LeGrandG S Dizerega
Mar 18, 1994·Science·R GrefR Langer
Aug 26, 1998·The New England Journal of Medicine·F D Lowy
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·M SinghD O'Hagan
May 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·El-Refaie KenawyGary E Wnek
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y K LuuM Hadjiargyrou
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Geert VerreckMarcus E Brewster

❮ Previous
Next ❯

Citations

Mar 3, 2009·Journal of Materials Science. Materials in Medicine·Markus Dietmar SchoferSusanne Fuchs-Winkelmann
Mar 13, 2012·Journal of Materials Science. Materials in Medicine·Timothy T RuckhKetul C Popat
Oct 12, 2012·Journal of Materials Science. Materials in Medicine·Nicole J OstrowskiPrashant N Kumta
Apr 26, 2013·Pharmaceutical Research·Panagiotis SofokleousMohan Edirisinghe
Nov 16, 2013·Archives of Pharmacal Research·Young Ju SonHyuk Sang Yoo
Nov 6, 2013·Antiviral Research·Anna K BlakneyKim A Woodrow
Jun 25, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Guorui JinSeeram Ramakrishna
Aug 30, 2008·Critical Reviews in Food Science and Nutrition·Christina KriegelJochen Weiss
Sep 16, 2008·Tissue Engineering. Part a·Xiaochuan YangHongjun Wang
Jun 28, 2011·Tissue Engineering. Part B, Reviews·Rebecca L DahlinAntonios G Mikos
Nov 5, 2005·Nucleic Acids Research·Dehai LiangBenjamin Chu
Sep 10, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael HromadkaJohn A van Aalst
Jun 5, 2013·Antimicrobial Agents and Chemotherapy·Tiaan D J HeunisLeon M T Dicks
Aug 28, 2010·Journal of Biomedicine & Biotechnology·T D J Heunis, L M T Dicks
Nov 11, 2011·International Journal of Nanomedicine·Jun ChenMalcolm M Q Xing
Aug 27, 2013·International Journal of Nanomedicine·Maedeh ZamaniSeeram Ramakrishna
Aug 28, 2007·International Journal of Nanomedicine·Rajesh Vasita, Dhirendra S Katti
Jul 1, 2008·Regenerative Medicine·Nureddin AshammakhiY Yang
May 30, 2014·International Journal of Nanomedicine·Ghulam JalaniDong Woo Lim
Apr 13, 2013·International Journal of Pharmaceutical Investigation·Thakur Prasad ChaturvediPushpendra Kumar Verma
Jul 24, 2012·Therapeutic Delivery·Kyung Jae Jeong, Daniel S Kohane
Apr 28, 2011·Biomicrofluidics·Koyal Garg, Gary L Bowlin
Aug 25, 2007·Nanomedicine·Erhan PiskinIsmail Alper Isoglu
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiuli HuXiabin Jing
Jul 1, 2014·Nanomedicine·Evžen AmlerAldo R Boccaccini
Jul 12, 2014·Annual Review of Analytical Chemistry·Lauren Matlock-Colangelo, Antje J Baeumner
May 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hongliang JiangKangjie Zhu
Sep 23, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·Yan JiXiaohong Wu
Sep 12, 2014·North American Journal of Medical Sciences·Ramta Bansal, Aditya Jain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
El-Refaie KenawyGary E Wnek
Journal of Controlled Release : Official Journal of the Controlled Release Society
Jing ZengXiabin Jing
Journal of Controlled Release : Official Journal of the Controlled Release Society
Jing ZengXiabin Jing
© 2022 Meta ULC. All rights reserved