PMID: 2106567Mar 1, 1990Paper

Incorporation, distribution, and turnover of arachidonic acid within membrane phospholipids of B220+ T cells from autoimmune-prone MRL-lpr/lpr mice

The Journal of Experimental Medicine
M Tomita-YamaguchiT J Santoro

Abstract

The metabolism of AA-containing phosphoglycerides within T cell membranes leads to the generation of second messengers that appear to play a crucial role in transmembrane signal transduction. To test the hypothesis that aberrations in the movement of arachidonoyl-phospholipids are associated with and may potentially contribute to abnormal T cell function, the incorporation, distribution, and turnover of AA within the membrane glycerolipids of cells that are known to exhibit immunoregulatory disturbances was examined. Thy-1+, Ly-1+, L3T4-, Lyt-2-, B220+ T cells from autoimmune MRL-lpr/lpr mice were used as the cellular model. In contrast to control lymph node T cells, which preferentially incorporate labeled AA into phosphatidylcholine (PC), B220+ T cells displayed a predilection for distributing [3H]arachidonate into phosphatidylinositol (PI). The arachidonoyl-phospholipid pools were normal in B220+ T cells. The constitutive turnover of [3H]arachidonoyl-PI was significantly enhanced and that of [3H]arachidonate-PC substantially reduced in B220+ T cell compared with control cells. Using membrane homogenates B220+ T cells demonstrated a functional increase in the levels of lyso-PI. Intact B220+ T cells prelabeled with [3H]myoinos...Continue Reading

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Citations

Sep 3, 2005·Autoimmunity Reviews·Masami TakeiShigemasa Sawada
Feb 3, 2004·Lipids in Health and Disease·Michiyo TomitaThomas J Santoro
Oct 8, 1999·Pharmacology & Therapeutics·N B Blatt, G D Glick
Feb 1, 1997·International Journal of Immunopharmacology·M MiharaY Takeda
Aug 23, 2011·Prostaglandins & Other Lipid Mediators·Karen WagnerBruce D Hammock
Aug 1, 1992·Cellular Immunology·S T FurlongH G Remold
Jan 2, 2013·European Journal of Pharmacology·Karen WagnerBruce D Hammock
Apr 30, 1993·Biochimica Et Biophysica Acta·S AndoT J Santoro

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