PMID: 737188Dec 22, 1978Paper

Incorporation, metabolism and positional distribution of trans-unsaturated fatty acids in developing and mature brain. Comparison of elaidate and oleate administered intracerebrally

Biochimica Et Biophysica Acta
H W Cook

Abstract

Mixtures of [1-14C]elaidic acid and [9,10-3H]oleic acid, as well as [1-14C]elaidic or [1-14C]oleic acid alone, were administered by intracerebral injection to 10-day old and adult rats to examine the relative incorporation and metabolism of trans- and cis-monounsaturated fatty acids in developing and mature brain. Rates and extents of total incorporation of label from trans- and cis-acid into complex lipids were similar. Maximum labeling of the neutral lipid, mainly triacylglycerol and cholesterol, occurred prior to 4 h after injection whereas phospholipid, mainly choline phosphoglyceride, was maximally labeled at 4--8 h after injection. The decrease in labeled phospholipid from 24 to 90 h was greater with elaidate than with oleate. At 8 h labeled elaidic acid was preferentially esterified in the 1-position of all phosphoglycerides whereas labeled oleic acid, in contrast to the positional distribution of endogenous oleate, was randomly distributed. Label from elaidate found in palmitate increased with time to 26% of the total recovered label by 48 h. Thus, although some of the trans-fatty acid is oxidized and its labeled carbon is redistributed, most is incorporated unaltered into complex lipid of brain at rates similar to thos...Continue Reading

References

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Citations

Jan 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H W CookM W Spence
Nov 1, 1981·Neurochemical Research·H W Cook
Oct 23, 2016·Chemistry and Physics of Lipids·Ali Reza Fardin-Kia
Oct 1, 2005·Chembiochem : a European Journal of Chemical Biology·Carla Ferreri, Chryssostomos Chatgilialoglu
Sep 15, 1995·Journal of Chromatography. B, Biomedical Applications·V Ruiz-Gutiérrez, L J Barron
Apr 18, 1980·Biochimica Et Biophysica Acta·K KamedaR T Holman
Jul 20, 1982·Biochimica Et Biophysica Acta·L D LawsonR T Holman

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