Incorporation of 2-amino-thiophene derivative in nanoparticles: enhancement of antifungal activity.

Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]
Wendell Wons NevesReginaldo Gonçalves de Lima-Neto

Abstract

The objective of this study was to evaluate the effects of nanoparticles (nanospheres and nanocapsules) of the promising antifungal 2-amino-thiophene (6CN10) and 6CN10 complexed with 2-hydroxypropyl-β-cyclodextrin (6CN10:HP-β-CD) in vitro and compared with free drug against Candida and Cryptococcus, using a microdilution method to measure susceptibility. The Candida and Cryptococcus clinical strains were identified using phenotypic methods and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF). To measure in vitro antifungal susceptibility, we used microdilution trials. Serial drug or nanoparticle dilutions were prepared according to the CLSI M27-A3 guidelines. Anti-biofilm activity was verified for Cryptococcus neoformans. All Candida isolates were sensitive to the free drug (MIC = 41.66-333.33 μg/mL) and were able to grow even at the higher concentration tested for all 6CN10 nanoparticles. However, the Cryptococcus neoformans strains presented MIC values of 0.32-83.33 μg/mL for 6CN10 nanoparticles, and MIC values of 0.1-0.2 μg/mL for 6CN10:HP-β-CD nanoparticles, i.e., 3333 times more active than the free drug (MIC values 166.66-333.33 μg/mL), and presenting activity greater than that of the reference drug ...Continue Reading

References

Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·John R. Perfect, Gary M. Cox
May 3, 2005·Bioorganic & Medicinal Chemistry Letters·Chung-Kyu RyuSeong Hee Jeong
Dec 31, 2005·Microbiology·A GuerreroB C Fries
May 16, 2006·FEMS Yeast Research·Neena JainBettina C Fries
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Aug 2, 2007·Canadian Journal of Microbiology·Olihile M SebolaiJohan L F Kock
Nov 15, 2007·Current Infectious Disease Reports·Helene C EisenmanErin E McClelland
Feb 5, 2010·The Journal of Antimicrobial Chemotherapy·Davy VandenboschTom Coenye
Mar 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luciana ScottiFrancisco Jaime Bezerra Mendonça Junior
Jul 4, 2012·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Beatriz C C SouzaFrancisco J B Mendonça
Apr 19, 2013·Letters in Applied Microbiology·T F F MagalhãesM A de Resende-Stoianoff
Sep 23, 2014·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Geovani Pereira GuimarãesJosé Alexsandro da Silva
Nov 12, 2016·Methods in Molecular Biology·David A EnochChristianne Micallef
May 10, 2017·The Lancet Infectious Diseases·Radha RajasinghamDavid R Boulware
Jul 26, 2017·International Immunopharmacology·Gabriel Barros RodriguesChristina Alves Peixoto
May 12, 2018·Nature Reviews. Disease Primers·Peter G PappasBart Jan Kullberg

❮ Previous
Next ❯

Methods Mentioned

BETA
nanoprecipitation
scanning electron microscopy

Software Mentioned

MALDI [UNK]
GraphPad Prism

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
T Hamamoto
Medical Mycology Journal
Reiko Ikeda
Current Biology : CB
Tami McDonaldKirsten Nielsen
Trends in Microbiology
François L Mayer, James W Kronstad
Canadian Journal of Medical Technology
M I LUNEY
© 2021 Meta ULC. All rights reserved