Incorporation of adult organ-derived endothelial cells into tumor blood vessel

Biochemical and Biophysical Research Communications
Keiichi KoizumiT Mayumi

Abstract

In this study, we attempted to assess the incorporable potential of vascular endothelial cells derived from adult organ blood vessels into tumor blood vessels. Two kinds of adult organ-derived vascular endothelial cells, human aorta endothelial cells (HAEC) and umbilical vein endothelial cells (HUVEC), were administered into murine tumors inoculated to SCID mice. Many human blood vessel networks were visualized in the murine tumors. These cells in solid tumor not only survived and proliferated, but also incorporated into tumor endothelium. These results suggest that adult organ-derived vascular endothelial cells possess the potential to form the neovascular network in various tissues such as vascular endothelial progenitor-like cells in vivo. We propose that these cells can be regarded as a congenic (autologous) vector for vascular regeneration cell therapy and tumor vascular targeting gene therapy.

References

Dec 1, 1977·Circulation Research·E M Renkin
Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams
Nov 18, 1971·The New England Journal of Medicine·J Folkman

❮ Previous
Next ❯

Citations

Sep 16, 2010·Herz·M U BecherN Werner
Sep 13, 2007·Biomedical Microdevices·Eric LeclercLaurent Griscom
Jan 22, 2009·Pathology International·So TakegoshiMakoto Naito
Mar 22, 2006·Pediatric Research·Chad L Barber, M Luisa Iruela-Arispe
Jul 6, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadanori Mayumi
Mar 12, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Shaun R Opie, Nabil Dib
Dec 7, 2005·Neurosurgery·Márcia Regina MacheinKarl Heinz Plate
Mar 10, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tuomas MäntyläSeppo Ylä-Herttuala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Microcirculation, Clinical and Experimental
N UtoguchiT Mayumi
Journal of Controlled Release : Official Journal of the Controlled Release Society
Susumu ImazuT Mayumi
Biochemical and Biophysical Research Communications
K TaniguchiT Mayumi
© 2022 Meta ULC. All rights reserved