PMID: 6162852Jan 1, 1981Paper

Incorporation of axonally transported glycoproteins into axolemma during nerve regeneration

The Journal of Cell Biology
J W GriffinJ Morris

Abstract

The insertion of axonally transported fucosyl glycoproteins into the axolemma of regenerating nerve sprouts was examined in rat sciatic motor axons at intervals after nerve crush. [(3)H]Fucose was injected into the lumbar ventral horns and the nerves were removed at intervals between 1 and 14 d after labeling. To follow the fate of the "pulse- labeled" glycoproteins, we examined the nerves by correlative radiometric and EM radioautographic approaches. The results showed, first, that rapidly transported [(3)H]fucosyl glycoproteins were inserted into the axolemma of regenerating sprouts as well as parent axons. At 1 d after delivery, in addition to the substantial mobile fraction of radioactivity still undergoing bidirectional transport within the axon, a fraction of label was already associated with the axolemma. Insertion of labeled glycoproteins into the sprout axolemma appeared to occur all along the length of the regenerating sprouts, not just in sprout terminals. Once inserted, labeled glycoproteins did not undergo extensive redistribution, nor did they appear in sprout regions that formed (as a result of continued outgrowth) after their insertion. The amount of radioactivity in the regenerating nerves decreased with time, ...Continue Reading

References

Jul 1, 1976·Journal of Neurobiology·J W GriffinD L Price
Mar 1, 1977·Journal of Neuropathology and Experimental Neurology·J W GriffinD B Drachman
Aug 1, 1977·Journal of Neurochemistry·M A Bisby, V T Bulger
Jul 1, 1977·Journal of Neurobiology·J W GriffinD B Drachman
Oct 1, 1978·The Journal of Cell Biology·M Estridge, R Bunge
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Oct 1, 1980·Experimental Neurology·A PestronkJ W Griffin

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Citations

Jul 13, 2005·Cell and Tissue Research·Elke K Buschbeck, Ronald R Hoy
Oct 1, 1981·Journal of the Neurological Sciences·J R MendellP Thibert
Nov 21, 1995·Brain Research. Developmental Brain Research·P S Lasiter, B B Bulcourf
Apr 1, 1996·Trends in Neurosciences·A H Futerman, G A Banker
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Mar 1, 1991·The Journal of Cell Biology·R O LockerbieK H Pfenninger
Jun 1, 1990·Journal of Neurocytology·J W GriffinB D Trapp
Jan 1, 1987·CRC Critical Reviews in Biochemistry·M Schwartz
Nov 1, 1992·Journal of Neurobiology·D L PriceL C Cork
Sep 19, 2009·Traffic·Meir Aridor, Kenneth N Fish
Apr 1, 1983·Journal of Neurochemistry·G C Stone, R Hammerschlag
Oct 1, 1983·Journal of Neurochemistry·J E YoshinoG H DeVries
Dec 1, 1985·Journal of Neurochemistry·M A Bisby
Jan 1, 1987·Journal of Neurochemistry·R D Rulli, D L Wilson
Nov 1, 1982·Journal of Neurochemistry·A D ToewsP Morell
Jun 1, 1985·Journal of Neurochemistry·T D LindquistN A Ingoglia
Jan 1, 1988·Annals of Neurology·J W Griffin, D F Watson
Dec 1, 1982·Journal of Neurochemistry·R M GouldN A Ingoglia

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