Incorporation of BMP-2 loaded collagen conjugated BCP granules in calcium phosphate cement based injectable bone substitutes for improved bone regeneration

Materials Science & Engineering. C, Materials for Biological Applications
Gun Hee LeeByongTaek Lee

Abstract

The objective of the present study was to incorporate surface modified porous multichannel BCP granule into CPC to enhance its in vivo biodegradation and bone tissue growth. The multichannel BCP granule (15wt%) was first coated with collagen subsequent to BMP-2 loading (ccMCG-B). It was then embedded into CPC to form CPC-ccMCG-B system. The newly developed CPC-ccMCG-B system was then examined for SEM, EDX, XRD, setting time, compressive strength, injectability, pH change, BMP-2 release, in vitro as well as in vivo studies and further compared with CPC. Optimized CPC (0.45mL/g) was found based on setting time and compressive strength studies. In vivo studies exhibited improved new bone formation and better degradation of CPC after 2 and 4weeks of implantation as compared to CPC as resulted from effective BMP-2 signaling. Our results suggest that CPC-ccMCG-B system might be used as a promising injectable bone substitutes in clinical applications.

Citations

Jan 23, 2018·Bone Research·Hockin Hk XuMark A Reynolds
Mar 6, 2019·Journal of Applied Biomaterials & Functional Materials·Hamid TebyanianNafiseh Baheiraei
Nov 14, 2019·Journal of Applied Biomaterials & Functional Materials·Azizeh-Mitra Yousefi
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Shithima SayedByong-Taek Lee
Feb 2, 2021·Journal of Biomaterials Applications·Karl WuChih-Hung Chang
Jan 18, 2021·Acta Biomaterialia·K HurleF Goetz-Neunhoeffer
Mar 25, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Hoe-Jin KangByong-Taek Lee
Apr 14, 2021·International Journal of Oral Science·Yan WeiHaibin Xia

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