Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs.

BMC Genetics
Yen-Feng ChiuChun-Yi Lee

Abstract

Many dichotomous traits for complex diseases are often involved more than one locus and/or associated with quantitative biomarkers or environmental factors. Incorporating these quantitative variables into linkage analysis as well as localizing two linked disease loci simultaneously could therefore improve the efficiency in mapping genes. We extended the robust multipoint Identity-by-Descent (IBD) approach with incorporation of covariates developed previously to simultaneously estimate two linked loci using different types of affected relative pairs (ARPs). We showed that the efficiency was enhanced by incorporating a quantitative covariate parametrically or non-parametrically while localizing two disease loci using ARPs. In addition to its help in identifying factors associated with the disease and in improving the efficiency in estimating disease loci, this extension also allows investigators to account for heterogeneity in risk-ratios for different ARPs. Data released from the collaborative study on the genetics of alcoholism (COGA) for Genetic Analysis Workshop 14 (GAW 14) were used to illustrate the application of this extended method. The simulation studies and example illustrated that the efficiency in estimating disease ...Continue Reading

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Citations

Dec 24, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·B K PodisiP M Hocking
Jan 22, 2013·Annals of Human Genetics·Yen-Feng ChiuFang-Chi Hsu

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Methods Mentioned

BETA
genotyping

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