Incorporation of high-dose 131 I-metaiodobenzylguanidine treatment into tandem high-dose chemotherapy and autologous stem cell transplantation for high-risk neuroblastoma: results of the SMC NB-2009 study

Journal of Hematology & Oncology
Ji Won LeeDo Hoon Lim

Abstract

In our previous SMC NB-2004 study of patients with high-risk neuroblastomas, which incorporated total-body irradiation (TBI) with second high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT), the survival rate was encouraging; however, short- and long-term toxicities were significant. In the present SMC NB-2009 study, only TBI was replaced with 131I-meta-iodobenzylguanidine (MIBG) treatment in order to reduce toxicities. From January 2009 to December 2013, 54 consecutive patients were assigned to receive tandem HDCT/auto-SCT after nine cycles of induction chemotherapy. The CEC (carboplatin + etoposide + cyclophosphamide) regimen and the TM (thiotepa + melphalan) regimen with (for metastatic MIBG avid tumors) or without (for localized or MIBG non-avid tumors) 131I-MIBG treatment (18 or 12 mCi/kg) were used for tandem HDCT/auto-SCT. Local radiotherapy, differentiation therapy with 13-cis-retinoic acid, and immunotherapy with interleukin-2 were administered after tandem HDCT/auto-SCT. Fifty-two patients underwent the first HDCT/auto-SCT and 47 patients completed tandem HDCT/auto-SCT. There was no significant immediate toxicity during the 131I-MIBG infusion. Acute toxicities during the tandem HDCT/auto-SCT...Continue Reading

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Citations

Aug 30, 2018·Children·Valeria Smith, Jennifer Foster
Aug 14, 2018·Nuclear Medicine and Molecular Imaging·Daiki Kayano, Seigo Kinuya
May 26, 2018·Pediatric Blood & Cancer·Ji Won LeeHong Hoe Koo
Oct 13, 2020·Nuclear Medicine Communications·Tara HaddadReza Vali
Feb 16, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Iwona MalinowskaBozenna Baginska-Dembowska
Jul 28, 2021·Expert Review of Clinical Pharmacology·Stefano MastrangeloAntonio Ruggiero

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