Incorporation of isotopically labeled cocaine into human hair: race as a factor

Journal of Analytical Toxicology
G L HendersonP Jacob

Abstract

In order to evaluate race as a possible factor affecting the incorporation of drugs into human hair, 2 mg/kg deuterium-labeled cocaine (cocaine-d5) was administered intranasally to nine male non-Caucasian volunteers under controlled laboratory conditions. Sequential blood samples were collected for up to three days, and scalp hair samples were collected at 24 and 72 h after dosing and at monthly intervals for up to 12 months. The samples were then analyzed by gas chromatography-mass spectrometry for cocaine-d5 and benzoylegonine-d5 (BZE-d5). The amounts of cocaine-d5 found in the hair of these non-Caucasian subjects were compared with the amounts of cocaine-d5 found in the hair of Caucasian subjects who received the same cocaine dose under identical conditions as part of a study we reported previously. The non-Caucasians in the present study had approximately 2.7 times more cocaine-d5 in their hair than the Caucasian subjects in the earlier study. In five of the non-Caucasian subjects, cocaine-d5 could be detected in hair within 24 h after dosing. Curiously, we were unable to detect any cocaine-d5 in one of the non-Caucasian subject's hair at any time after dosing even though cocaine-d5 was in plasma at the expected levels. The...Continue Reading

Citations

Dec 15, 2010·International Journal of Legal Medicine·Ping XiangMin Shen
Jun 1, 2005·Neurotoxicology and Teratology·Fonda Davis EylerIan Tebbett
Dec 3, 2002·Journal of Chromatography. a·Birgit Dräger
Feb 26, 2000·Forensic Science International : Synergy·T Mieczkowski, R Newel
Feb 26, 2000·Forensic Science International : Synergy·D A KidwellS F DeLauder
Feb 26, 2000·Forensic Science International : Synergy·P KintzB Ludes
May 24, 2006·International Journal of Toxicology·Vassiliki A BoumbaTheodore Vougiouklakis
May 10, 2013·Journal of Analytical Toxicology·Xiaopei CuiMin Shen
Feb 16, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Benjamin J ApelbergPatrick N Breysse
Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Marie Balíková
Jan 2, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·John Curtis, Michael Greenberg
Sep 4, 2012·Clinics in Laboratory Medicine·Donald L Frederick
Nov 4, 2011·Chemosphere·Reza Dahmardeh BehroozAbbas Esmaili-Sari
Jun 13, 2008·Chemosphere·K-W Schramm
Oct 11, 2015·Journal of Forensic and Legal Medicine·Ping XiangOlaf H Drummer
Oct 23, 2015·Journal of Forensic and Legal Medicine·Valérie Baillif-CouniouAnne-Laure Pelissier-Alicot
Jun 3, 2004·Forensic Science International : Synergy·Pascal Kintz
Sep 12, 2006·Forensic Science International : Synergy·Marilyn A HuestisMichael L Smith
Apr 21, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Fritz Pragst, Marie A Balikova
Jul 17, 2012·Psychiatry Research·Richard A Van DornMarvin S Swartz
Jan 9, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alice AmelinePascal Kintz
Oct 10, 2002·Substance Use & Misuse·Rebekah K HerschRoyer F Cook
Nov 26, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M A HuestisR E Joseph
Jun 1, 2021·Sociology of Health & Illness·Celia Roberts, Brigit McWade
Feb 27, 2013·Pediatrics·Marylou BehnkeUNKNOWN Committee on Fetus and Newborn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.