PMID: 3747494Jul 1, 1986Paper

Incorporation of microporous Teflon tracheal prostheses in rabbits: evaluation of surgical aspects

The Journal of Surgical Research
J R Bottema, C H Wildevuur

Abstract

Because tracheal prostheses made of nonporous silicone rubber develop granulation tissue at the anastomoses, we tested a prosthesis made of a microporous material (polytetrafluoroethylene, Teflon) to see whether this problem could be avoided and the prosthesis could be successfully incorporated (luminal side covered by connective tissue and epithelium). At various times after implantation in the cervical trachea of rabbits, the prostheses were inspected macroscopically for obstruction of the prosthesis lumen (lumen reduced by one-third or more) and microscopically for incorporation and inflammatory reaction (concentration of inflammatory cells) of the prosthesis. The prosthesis was successfully incorporated within 2-4 weeks in most rabbits without granulation tissue at the anastomoses. Two complications were infection of the prosthesis before incorporation was completed and obstruction of the lumen in the center of the prosthesis by granulation tissue or a deformed prosthesis wall. Both problems can be overcome, the first by giving an appropriate antibiotic for a longer period and the second by making a stiffer prosthesis. Thus, the microporous Teflon prosthesis is potentially useful as a tracheal prosthesis in rabbits.

References

Dec 1, 1970·The Journal of Thoracic and Cardiovascular Surgery·J Borrie, N R Redshaw
Jan 1, 1968·The Annals of Thoracic Surgery·R R ShawW R Webb

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Citations

Nov 1, 1991·Journal of Surgical Oncology·A ShahaB M Jaffe
Jun 25, 2002·The Annals of Thoracic Surgery·Hermes C Grillo
Jun 1, 1989·Artificial Organs·H H SchauweckerE S Bücherl
Jun 16, 2007·In Vitro Cellular & Developmental Biology. Animal·Cosima PfenningerMichael Sittinger
Nov 24, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·P SchultzC Debry
Jul 20, 2016·Interactive Cardiovascular and Thoracic Surgery·Yu LiuQun Wang
Sep 30, 2003·Asian Cardiovascular & Thoracic Annals·Ali Dodge-KhatamiBas A J M de Mol
Sep 22, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Amy E DossJoseph B Zwischenberger
Mar 1, 1989·Equine Veterinary Journal·C V FosterE J Pouret
Apr 1, 1990·Acta paediatrica Scandinavica·J D Lloyd-StillH U Wessel
Jan 1, 1990·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·G HanffG Lundborg

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