Incorporation of nanofibrillated chitosan into electrospun PCL nanofibers makes scaffolds with enhanced mechanical and biological properties

Carbohydrate Polymers
Milad FadaieZahra Asvar

Abstract

Fabricating polycaprolactone (PCL) composite can be a facile approach to improve wettability, mechanical properties and cellular compatibility of PCL-based scaffolds. In this study, nanofibrillated chitosan (NC) was utilized as dispersing phase in PCL matrix to acquire electrospun nanocomposite fibrous scaffolds. Various amounts of NC were added to PCL solutions and the solutions were electrospun under constant electrospinning parameters. Adding NC to PCL solutions was accompanied with notable changes in the solutions viscosity, conductivity and electrospinnability. Whiles the pure PCL solutions with concentration of 8 wt. % and 10 wt. % were not electrospinnable, adding 5-10 % NC made them electrospinnable. The mechanical properties, wettability and cellular compatibility of electrospun PCL/NC composites were improved as well. PCL/NC scaffolds showed remarkable enhancement in both tensile strength and Young's modulus compared to neat PCL scaffold. Contact angle measurements revealed improvement in wettability of scaffolds after adding NC. In addition, proliferation and adhesion of cells was enhanced when NC was incorporated to nanofibers. The results suggest PCL/NC as a proper scaffold for tissue engineering applications.

Citations

May 9, 2019·Biomedical Materials·Ahmet Ozan BasarHilal Turkoglu Sasmazel
Nov 28, 2019·Journal of Biomaterials Science. Polymer Edition·Fangwen ZhaDemei Yu
Sep 13, 2020·Nanomaterials·Sara PolitiLaura Teodori
Nov 8, 2020·Journal of Materials Science. Materials in Medicine·Mei-Chen LinYueh-Sheng Chen
Nov 25, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xingzi LanYadong Tang
Mar 11, 2021·Molecular Biotechnology·Nadeem SiddiquiEsmaiel Jabbari
Aug 2, 2021·International Journal of Biological Macromolecules·Marziyeh Ranjbar-MohammadiZahra Arab-Bafrani

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