Incorporation of omics analyses into artificial gravity research for space exploration countermeasure development

Metabolomics : Official Journal of the Metabolomic Society
Michael A SchmidtRalph Pelligra

Abstract

The next major steps in human spaceflight include flyby, orbital, and landing missions to the Moon, Mars, and near earth asteroids. The first crewed deep space mission is expected to launch in 2022, which affords less than 7 years to address the complex question of whether and how to apply artificial gravity to counter the effects of prolonged weightlessness. Various phenotypic changes are demonstrated during artificial gravity experiments. However, the molecular dynamics (genotype and molecular phenotypes) that underlie these morphological, physiological, and behavioral phenotypes are far more complex than previously understood. Thus, targeted molecular assessment of subjects under various G conditions can be expected to miss important patterns of molecular variance that inform the more general phenotypes typically being measured. Use of omics methods can help detect changes across broad molecular networks, as various G-loading paradigms are applied. This will be useful in detecting off-target, or unanticipated effects of the different gravity paradigms applied to humans or animals. Insights gained from these approaches may eventually be used to inform countermeasure development or refine the deployment of existing countermeas...Continue Reading

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Citations

Oct 27, 2018·Omics : a Journal of Integrative Biology·Mustafa BayramVural Özdemir
Dec 20, 2017·International Journal of Molecular Sciences·Jorge S Burns, Gina Manda
May 18, 2021·IScience·Swati BijlaniClay C C Wang

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