PMID: 3756528Sep 1, 1986Paper

Incorporation of plasma palmitate into the brain of the rat during development

Brain Research
H TabataS I Rapoport

Abstract

Jpalm, the rate of incorporation of plasma palmitate into brain, was determined in awake Fischer-344 rats at 15, 20, 25 and 38 days of age, by a modification of the method of Kimes et al. [14C]palmitate was injected intravenously and plasma-specific activity of unesterified palmitate was followed until the animals were killed at 4 h, when radioactivity was determined by quantitative autoradiography in 45 individual brain regions. Jpalm was calculated as the 4 h brain radioactivity divided by integrated plasma palmitate-specific activity to 4 h. Jpalm rose between 15 and 20 days of age in gray and white matter regions, then declined 4-5-fold in gray matter and 7-10-fold in white matter by 38 days and reached adult levels by 3 months. The white/gray ratio for Jpalm declined significantly between 20 and 38 days, and between 38 days and 3 months of age, consistent with a lower rate of turnover of white matter lipids in the mature brain. The results support the use of the Jpalm technique to measure brain lipid synthesis and turnover. They show that Jpalm corresponds to the time course of myelination during development of the rat brain, when there are parallel changes in the rates of palmitate incorporation into gray and white matter...Continue Reading

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Citations

Mar 1, 1996·Neurobiology of Aging·S K BriningM C Chang
Sep 1, 1989·Clinical and Experimental Pharmacology & Physiology·P J Robinson, S I Rapoport
Apr 1, 1991·Journal of Neurosurgery·T NariaiS I Rapoport
Feb 18, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Epolia RamadanMireille Basselin
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·B SchmallS M Larson
Aug 4, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Zhi-Xin Yuan, Stanley I Rapoport
Apr 2, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sheila M Innis, Carolanne M Nelson
Jun 1, 1990·Journal of Neuroscience Research·J G NoronhaS I Rapoport
Nov 1, 1987·Stroke; a Journal of Cerebral Circulation·O ToneS I Rapoport
Jul 8, 2015·Neurochemical Research·Mary C McKennaCourtney L Robertson
Jan 1, 1988·Neurochemical Research·J M GnaedingerS I Rapoport

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